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Pregled bibliografske jedinice broj: 541684

Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells


Puljiz, Ivan; Markotić, Alemka; Cvetko Krajinović, Lidija; Gužvinec, Marija; Polašek, Ozren; Kuzman, Ilija
Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells // Medical science monitor, 18 (2012), 8; 500-505 doi:10.12659/MSM.883270 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 541684 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells

Autori
Puljiz, Ivan ; Markotić, Alemka ; Cvetko Krajinović, Lidija ; Gužvinec, Marija ; Polašek, Ozren ; Kuzman, Ilija

Izvornik
Medical science monitor (1234-1010) 18 (2012), 8; 500-505

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mycoplasma pneumoniae; pneumonia; matrix metalloproteinase-9

Sažetak
The objective of this study was to assess the concentration of metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) in peripheral circulation and their mRNA expression in peripheral blood mononuclear cells (PBMCs) in patients with CAP caused by M. pneumoniae.We prospectively analyzed MMPs in 40 hospitalized patients with M. pneumoniae CAP on admission, and in the convalescent phase. Twenty healthy men were used as controls. Quantitative real-time PCR and ELISA tests were used.MMP-9 mRNA expression in PBMCs was increased in the acute phase of illness compared to the control group as well as in convalescent phase in which case it was statistically significant (Mann- Whitney ; p=0.028). The same was found for MMP-9 plasma levels (Mann-Whitney test ; p<0.001 ; p=0.001). Circulating MMP-2 concentration in acute patients was significantly lower than in the control group and convalescent phase (Mann-Whitney test ; p=0.012 ; p=0.001), while no MMP-2 mRNA expression was found in PBMCs. The plasma level of MMP-9 correlated with leukocyte count in peripheral circulation (r=0.67, p<0.001).We conclude that M. pneumoniae in adult CAP induces activity of MMP-9 in peripheral blood circulation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-3491 - ISTRAŽIVANJE ETIOLOGIJE I PATOGENEZE PNEUMONIJA (Kuzman, Ilija, MZOS ) ( POIROT)
143-1080002-0101 - Detekcija i karakterizacija uzročnika bakterijskih meningitisa i pneumonija (Tambić Andrašević, Arjana, MZOS ) ( POIROT)
143-1430115-0103 - Imunoreakcije na hantaviruse i leptospire (Markotić, Alemka, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Citiraj ovu publikaciju

Puljiz, Ivan; Markotić, Alemka; Cvetko Krajinović, Lidija; Gužvinec, Marija; Polašek, Ozren; Kuzman, Ilija
Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells // Medical science monitor, 18 (2012), 8; 500-505 doi:10.12659/MSM.883270 (međunarodna recenzija, članak, znanstveni)
Puljiz, I., Markotić, A., Cvetko Krajinović, L., Gužvinec, M., Polašek, O. & Kuzman, I. (2012) Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells. Medical science monitor, 18 (8), 500-505 doi:10.12659/MSM.883270.
@article{article, year = {2012}, pages = {500-505}, DOI = {10.12659/MSM.883270}, keywords = {Mycoplasma pneumoniae, pneumonia, matrix metalloproteinase-9}, journal = {Medical science monitor}, doi = {10.12659/MSM.883270}, volume = {18}, number = {8}, issn = {1234-1010}, title = {Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells}, keyword = {Mycoplasma pneumoniae, pneumonia, matrix metalloproteinase-9} }
@article{article, year = {2012}, pages = {500-505}, DOI = {10.12659/MSM.883270}, keywords = {Mycoplasma pneumoniae, pneumonia, matrix metalloproteinase-9}, journal = {Medical science monitor}, doi = {10.12659/MSM.883270}, volume = {18}, number = {8}, issn = {1234-1010}, title = {Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells}, keyword = {Mycoplasma pneumoniae, pneumonia, matrix metalloproteinase-9} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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