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Fungal infections in intensive care units(ICUs) (CROSBI ID 476928)

Prilog sa skupa u zborniku | stručni rad | međunarodna recenzija

Jandrlić, M ; Tripković, V ; Sekulić, A Fungal infections in intensive care units(ICUs) // Control of hospital infections in intensive care units. Zagreb: Medicinski fakultet Sveučilišta u Zagrebu, 2000. str. 33-35-x

Podaci o odgovornosti

Jandrlić, M ; Tripković, V ; Sekulić, A

engleski

Fungal infections in intensive care units(ICUs)

Care in specialized units and the use of invasive monitoring devices, parenteral nutrition, broad spectrum antibacterial agents, and assisted ventilation have helped to treat severely ill patients. These risk patients are highly susceptible to nosocomial infections caused by organisms such as fungi. These opportunistic organisms were previously considered to be of low virulence. Fungal infections in these patients are often severe, rapidly progressive and difficult to diagnose or treat. Over the past two decades many hospitals reported an increase in the rate of nosocomial fungal infections, i.e. 2-5 fold increase per 1000 discharges. High rate of infections occurs on the oncology ward and ICHs (<20%). The proportion of infections caused by Candida spp. also increased. Overall crude mortality rate is 50-60 % and attributive mortality is approximately 38%. Frequently identified risk factors for fungemia are antimicrobial agents (number and duration), corticosteroid, solid organ transplantation, inwelling catheter, total parenteral nutrition, major operations, assisted ventilation, hemodialysis, previous colonisation (bacterial, fungal).... Most nosocomial candidemia are endogenous. Its sources are on the mouth, gastrointestinal tract or skin. Low percentage of exogenous acquisition of candidemia is possible through cross-transmission of yeast strains from healthcare workers to patients. Molecular diagnosis is useful for typing, identification and rapid diagnosis of possible epidemic fungal infections. All candidemic patients should be treated with antifungal drugs such as fluconazole or amphotericin B. The highest mortality associated with untreated or inadequately treat candidemic patients. On the other hand the increasing use of sistemic antifungal agents in profilaxis and therapy raises the emergence of resistant fungi, particularly Candida spp. An increasing number of imunocompromised hosts as risk of opportunistic fungal infections are more widespread use of antifungal agents both are factors that can influence occurence of yeast as pathogens. The prevalence of non-albicans Candida has increased as well as resistance to fluconazole, particularly among oncological patients. Because of that we must identify yeast to the species level, from surveillance and diagnostic cultures, and we need susceptibility testing of yeast from patients with risk.

fungal infections; intensive care units

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Podaci o prilogu

33-35-x.

2000.

objavljeno

Podaci o matičnoj publikaciji

Control of hospital infections in intensive care units

Zagreb: Medicinski fakultet Sveučilišta u Zagrebu

Podaci o skupu

9 th Clinical Microbiology Postgraduate Course

predavanje

01.01.2000-01.01.2000

Zagreb, Hrvatska

Povezanost rada

nije evidentirano