engleski

N-terminal proBNP and high sensitivity cardiac troponin I concetration in haemodialisis patients

Assessment ofserum biomarkers that are useful in stratification of early mortality and cardiovascular risk is very important in the treatment of patients on chronic haemodialysis. This study examinedthe relationship between high sensitivity cTnI and NT-proBNP according to glomerular filtration rates and vascular access (native AV-fistula or permanent catheter) in patients on haemodialysis. NT-proBNP and cTnI were measured by Vitros 3600 Immunodiagnostic System (Orthoclinical Diagnostic, Johnson & Johnson Company, USA) in 100 patients on haemodialysis. Concentrations of cTnI and NT-pro BNP were increased in 35% and 100% of patients. According to their residual renal function, patients were divided in three groups: oligoanuric, 02-05 L/24H and 05 –1 L/24h. The highest concentrations of NT-proBNP were in the first group and the third group showed the lowest NT-proBNP levels (p<0.05). The cTnI concentrations showed no statistically significant differences between these groups. Patients with fistula accesses had lower levels of cTnI and NT-proBNP than patients with permanent catheter, but these differenceswere not statistically significant. In patients with end-stage renal disease, interpretation of NT-proBNP levels should take into account residual diuresis. On the basis of our results, we suppose that high levels of cTnI should be interpreted only as a consequence of myocardial necrosis.

pro BNP; hemodijaliza; troponin I

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