engleski

Comparative Study on Gene Tags of the Neurotransmission System in Schizophrenic and Suicidal Subjects

Schizophrenia and suicidal behaviour are sever and complex mental disorders, largely determined by factors of in-heritance.Both disorders present pathological changes in the catecholamine neurotransmitter system.The study was conducted on three groups ; a group of subjects suffering from schizophrenia, a second compounded by individuals who attempted suicide and a third group of phenotypically healthy examinees.The blood samples of schizophrenic patients as of those who attempted suicide were obtained at the Psychiatric Hospital »SvetiIvan« in Zagreb in the year 2004.Tests we the statistic relation between a total of 18 SNPs with in three candidate-genes of the dopamine and aderenegic system (DRD4, SLC6A3andADRA2B)and the manifestation of schzophrenia and suicidal behaviour.Cases were genotyped by use of SNPlex system.Statistically significant differences were determined in the alleli cfrequency be- tween the mentioned groups.Findings show a siginficant connection between 4SNPs(ADRA2Brs749457, SLC6A3 rs464094, DRD4rs11246226andrs4331145)and schizophrenia, and 2SNPs with suicidal attempt(ADRA2Brs1018351i SLC6A3rs403636).In addition, this is the first study that highlights the potential role/effect of polymorphisms in ADRA2B on suicidal behaviour.

association; candidate-genes; Croatia; polymorphisms; schizophrenia

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