engleski

Implication of oxidative stress in development of Balkan endemic nephropathy and urinary tract toumors

Balkan endemic nephropathy (BEN) is human, chronic, tubulointerstitial renal disease that occurs in rural areas of Bosnia and Herzegovina, Croatia, Serbia and Romania. The disease is insidious and fatal, and mostly affects persons in their sixties or seventies. Epidemiologic survey from spring 2005 in Croatia showed that the prevalence of BEN is the same (0.6-2.3 %) as in past decades making this disease still serious health problem. BEN areas have unusually high rates of otherwise rare upper urinary trac tumours (UTT). Thes tumours are usually multiple and malignant localized mostly bilaterally in the renal pelvis, while the localization in the urinary bladder is not higher than in other regions. In the period 1995-2002 specific mortality of all patients with UTT in BEN area in Croatia was 14 times higher than in the rest of the region with BEN area and tt times higher than overall in Croatia. Since extensive production of reactive oxygen species leading to oxidative stress has been implicated in development of BEN and UTT. Urine samples were collected from a BEN village (N=22) and a control village (N=16) apparently healthy individuals. Urine samples were anallyzed for presence of product of llipid peroxidation, malondialdehyde (MDA) and product of oxidative damaged DNA, 8-hydroxy-2'deoxyguanosine (8-oxodG). The levels of both oxidative stress biomarkers were significantly higher in the BEN village residents than in controls (p<0.05). However, there was no correlation between MDA and 8-oxodG results (p=0.1965). Our results confirm that oxidative stress could be implilcated in develpment of both, BEN an UTT.

Balkan endemic nephropathy; urinary tract toumors; oxidative stress

nije evidentirano