engleski

Spontaneous disappearance of tissue transglutaminase antibodies is common in children diagnosed with type 1 diabetes mellitus

Aim was to investigate the prevalence of spontaneous normalization of tissue transglutaminase antibodies (TTG) in patients diagnosed with Type 1 Diabetes Mellitus (T1DM). Retrospective analysis of children diagnosed with T1DM and identified patients with elevated serum TTG. Patients were analyzed in 2 groups: Diagnosed with Celiac Disease (CD) and patients with spontaneous normalization of TTG. There were 48/738 (6.5%) patients with elevated TTG blood levels. Of these, CD was diagnosed in 23. From the remaining 25 patients, TTG antibodies disappeared on gluten containing diet in 17/48 (35.4%) children. A year after diagnosis, there was no significant difference between the groups neither in the HbA1c levels nor in the anthropometric measurements. Physicians treating T1DM patients should consider 12 months serologic follow up on GCD rather than immediate duodenal biopsy at least in children with mildly elevated TTG.

Celiac disease; TTG; Diabetes mellitus

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