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The evolutionary origin of orphan genes


Diethard, Tautz; Domazet-Lošo, Tomislav
The evolutionary origin of orphan genes // Nature reviews genetics, 12 (2011), 10; 692-702 doi:10.1038/nrg3053 (međunarodna recenzija, članak, znanstveni)


Naslov
The evolutionary origin of orphan genes

Autori
Diethard, Tautz ; Domazet-Lošo, Tomislav

Izvornik
Nature reviews genetics (1471-0056) 12 (2011), 10; 692-702

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Lineage-specific genes; protein evolution; eukaryotic evolution; inverse relationship; mammalian genes; expressed genes; genomic orfans; noncoding dna; evo-devo; drosophila

Sažetak
Gene evolution has long been thought to be primarily driven by duplication and rearrangement mechanisms. However, every evolutionary lineage harbours orphan genes that lack homologues in other lineages and whose evolutionary origin is only poorly understood. Orphan genes might arise from duplication and rearrangement processes followed by fast divergence ; however, de novo evolution out of non-coding genomic regions is emerging as an important additional mechanism. This process appears to provide raw material continuously for the evolution of new gene functions, which can become relevant for lineage-specific adaptations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
098-0982913-2832 - Evolucija i funkcija brzo evoluirajućeg dijela eukariotskog genoma (Đurđica Ugarković, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Tomislav Domazet-Lošo, (277566)

Citiraj ovu publikaciju

Diethard, Tautz; Domazet-Lošo, Tomislav
The evolutionary origin of orphan genes // Nature reviews genetics, 12 (2011), 10; 692-702 doi:10.1038/nrg3053 (međunarodna recenzija, članak, znanstveni)
Diethard, T. & Domazet-Lošo, T. (2011) The evolutionary origin of orphan genes. Nature reviews genetics, 12 (10), 692-702 doi:10.1038/nrg3053.
@article{article, year = {2011}, pages = {692-702}, DOI = {10.1038/nrg3053}, keywords = {lineage-specific genes, protein evolution, eukaryotic evolution, inverse relationship, mammalian genes, expressed genes, genomic orfans, noncoding dna, evo-devo, drosophila}, journal = {Nature reviews genetics}, doi = {10.1038/nrg3053}, volume = {12}, number = {10}, issn = {1471-0056}, title = {The evolutionary origin of orphan genes}, keyword = {lineage-specific genes, protein evolution, eukaryotic evolution, inverse relationship, mammalian genes, expressed genes, genomic orfans, noncoding dna, evo-devo, drosophila} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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