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Simvastatin decreases malondialdehyde level in plasma and tissues of rats

Introduction. It is considered that beneficial effect of simvastatin treatment on cardiovascular morbidity is due to its antioxidant activity. Simvastatin also shows antioxidant properties in cisplatin-induced nephrotoxicity and hepatotoxicity. The aim of this study was to compare the effect of simvastatin on the malondialdehyde level in plasma and different tissues of rats and to establish whether antioxidant effects exist after discontinuation of its administration. Material and methods. Two groups of male rats were under simvastatin treatment which was given orally (10 mg/kg/day for 3 weeks). At the end of the drug treatment, the first group was sacrificed and blood and tissue (heart, brain, liver, kidney)samples were taken. Other group was without the for the next 9 days (recovery period) and than sacrificed. The malondialdehyde level was measured in plasma (ı`mol/l) and tissue (ı`mol/g tissue) by spectrophotometric method. The results are expressed as the percentage of the decrease of malondialdehyde level and are compared to the control group. Data were analyzed by t-test. Results. Simvastatin decreased malondialdehyde level in plasma and all tissue by 20-40%. The same decrease of malondialdehyde was established in the recovery period, i.e.9 day after the last dose. Conclusion. Our results have shown that simvastatin exhibits the significant antioxidant effectiveness which persists after therapy discontinuation.

simvastatin; malondialdehyde; plasma; tissue; rats

DOI: 10.1111/j.1742-7843.2010.00600.x