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Pregled bibliografske jedinice broj: 538174

A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK)


Krištafor, Svjetlana; Novaković, Ivana; Gazivoda Kraljević, Tatjana; Kraljević Pavelić, Sandra; Lučin, Pero; Westermaier, Yvonne; Pernot, Lucile; Scapozza, Leonardo; Ametamey, Simon; Raić-Malić, Silvana
A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK) // Bioorganic & medicinal chemistry letters, 21 (2011), 20; 6161-6165 doi:10.1016/j.bmcl.2011.07.115 (međunarodna recenzija, članak, znanstveni)


Naslov
A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK)

Autori
Krištafor, Svjetlana ; Novaković, Ivana ; Gazivoda Kraljević, Tatjana ; Kraljević Pavelić, Sandra ; Lučin, Pero ; Westermaier, Yvonne ; Pernot, Lucile ; Scapozza, Leonardo ; Ametamey, Simon ; Raić-Malić, Silvana

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 21 (2011), 20; 6161-6165

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
6-(1; 3-Dihydroxyisobutenyl)thymine; Herpes simplex virus type 1 thymidine kinase (HSV-1 TX); Molecular docking; Positron emission tomography (PET)

Sažetak
Molecular modeling and phosphorylation assay in vitro were employed to select a novel unsaturated 1, 3-dihydroxyisobutenyl thymine derivative 6 as ligand for HSV-1 TK which may be of interest as lead for the development of an positron emission tomography (PET) imaging agent. Compound 6 was successfully prepared using modified approaches. A significant improvement over the syntheses involving pathways A and B (1% and 3% overall yield, respectively), was observed using synthetic route C (14% overall yield).

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
062-0620238-0223 - Sortiranje MHC-I molekula na staničnoj membrani i endocitoznim odjeljcima (Pero Lučin, )
125-0982464-2925 - Razvoj i primjena novih molekula u pozitron-emisijskoj tomografiji (PET) (Silvana Raić-Malić, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Ustanove
Medicinski fakultet, Rijeka,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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