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NK cell lymphoma, nasal type, with massive lung involvement: a case report

Extranodal NK/T-cell lymphoma, nasal type, is an Epstein Barr virus-associated lymphoma that most commonly involves the nasal cavity and upper respiratory tract. Lung involvement by NK/T-cell lymphoma is rare and seldom reported in the literature. We describe the unusual case of a 41-year-old male with NK-cell lymphoma, nasal type, who presented with massive secondary lung involvement two and one-half years after detection of a retroperitoneal mass. The diagnosis was made by open lung biopsy. Despite aggressive treatment, the patient died shortly after the initiation of therapy. Lung involvement by NK/T-cell lymphoma occurs most commonly as part of widely-disseminated disease and carries a poor prognosis for the patient. Novel agents and innovative therapies need to be developed for this aggressive lymphoma.

extranodal NK/T-lymphoma; lung involvement; Epstein-Barr virus

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