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Treatment of steroid unresponsive relapse with plasma exchange in aggressive multiple sclerosis


Habek, Mario; Barun, Barbara; Puretić, Zvonimir; Brinar, Vesna
Treatment of steroid unresponsive relapse with plasma exchange in aggressive multiple sclerosis // Therapeutic apheresis and dialysis, 14 (2010), 3; 298-302 doi:10.1111/j.1744-9987.2009.00794.x (međunarodna recenzija, članak, znanstveni)


Naslov
Treatment of steroid unresponsive relapse with plasma exchange in aggressive multiple sclerosis

Autori
Habek, Mario ; Barun, Barbara ; Puretić, Zvonimir ; Brinar, Vesna

Izvornik
Therapeutic apheresis and dialysis (1744-9979) 14 (2010), 3; 298-302

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aggressive; multiple sclerosis; plasma exchange; relapse

Sažetak
The options for treating steroid unresponsive relapses in relapsing remitting multiple sclerosis (RRMS) are modest. We present a small series of patients with an aggressive course of RRMS whose steroid unresponsive relapses were treated with plasma exchange. In the period from January 2007 until February 2009 we identified four patients with steroid unresponsive relapses. All recorded relapses were treated with methylprednisolone, either with 500 mg for 5 days or 1000 mg for 3 days. If there was no improvement, patients were given five cycles of plasma exchange. If there was no recovery after the initial five cycles, five more were administered. Each patient's clinical status was monitored using the extended disability status scale. The median time from symptom onset until starting plasma exchange was 30 days (23–45 days). For four relapses, five cycles of plasma exchange were given with marked recovery in one, moderate in two, and mild in one case. In one patient, after five cycles there was no recovery, so five more cycles were administered, after which a moderate recovery ensued. This study further supports the efficacy of plasma exchange in the treatment of steroid unresponsive relapses in aggressive RRMS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-0131484-0032 - Sustav poremećaja kortikalnih funkcija u neurološkim bolestima (Zdenko Mubrin, )
108-1080315-0297 - Odrednice i rana dijagnoza bolesti motoričkih neurona u populaciji Hrvatske (Ervina Bilić, )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zvonimir Puretić (autor)

Avatar Url Barbara Barun (autor)

Avatar Url Vesna Brinar (autor)

Avatar Url Mario Habek (autor)

Citiraj ovu publikaciju

Habek, Mario; Barun, Barbara; Puretić, Zvonimir; Brinar, Vesna
Treatment of steroid unresponsive relapse with plasma exchange in aggressive multiple sclerosis // Therapeutic apheresis and dialysis, 14 (2010), 3; 298-302 doi:10.1111/j.1744-9987.2009.00794.x (međunarodna recenzija, članak, znanstveni)
Habek, M., Barun, B., Puretić, Z. & Brinar, V. (2010) Treatment of steroid unresponsive relapse with plasma exchange in aggressive multiple sclerosis. Therapeutic apheresis and dialysis, 14 (3), 298-302 doi:10.1111/j.1744-9987.2009.00794.x.
@article{article, year = {2010}, pages = {298-302}, DOI = {10.1111/j.1744-9987.2009.00794.x}, keywords = {aggressive, multiple sclerosis, plasma exchange, relapse}, journal = {Therapeutic apheresis and dialysis}, doi = {10.1111/j.1744-9987.2009.00794.x}, volume = {14}, number = {3}, issn = {1744-9979}, title = {Treatment of steroid unresponsive relapse with plasma exchange in aggressive multiple sclerosis}, keyword = {aggressive, multiple sclerosis, plasma exchange, relapse} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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