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Pregled bibliografske jedinice broj: 537912

Genes associated with multiple sclerosis: 15 and counting


Habek, Mario; Brinar, Vesna; Borovečki, Fran
Genes associated with multiple sclerosis: 15 and counting // Expert review of molecular diagnostics, 10 (2010), 857-861 doi:10.1586/erm.10.77 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Genes associated with multiple sclerosis: 15 and counting

Autori
Habek, Mario ; Brinar, Vesna ; Borovečki, Fran

Izvornik
Expert review of molecular diagnostics (1473-7159) 10 (2010); 857-861

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
genetics; genome-wide association study; IL12A; MPHOSPH9/CDK2AP1; multiple sclerosis; RGS1

Sažetak
Multiple sclerosis (MS) develops in genetically susceptible populations as a result of environmental exposures, and discovering these genetic and/or environmental factors will provide fundamental new insights into the pathogenesis, diagnosis and treatment of this disabling disease. With the introduction of genome-wide association studies, the number of genes found to be associated with MS has increased rapidly. In all of these genes, in a study by the International Multiple Sclerosis Genetics Consortium, the classic MS risk locus, HLA-DRB1, stood out with remarkably strong statistical significance, but they also identified 12 other loci and/or genes associated with MS. However, all of these alleles have a very modest odds ratio and they explain approximately 3% of the variance in MS risk. Recently, the International Multiple Sclerosis Genetics Consortium provided evidence for three new loci that show significant association at a genome-wide level: RGS1, IL12A and MPHOSPH9/CDK2AP1. In this article, we will review the three newly discovered susceptibility loci and the implications of genome-wide association studies in MS on clinical practice.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081874-1923 - Genomska analiza transkriptoma i interaktoma u bolesnika s kompleksnim bolestima (Fran Borovečki, )
108-0131484-0032 - Sustav poremećaja kortikalnih funkcija u neurološkim bolestima (Zdenko Mubrin, )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Fran Borovečki (autor)

Avatar Url Vesna Brinar (autor)

Avatar Url Mario Habek (autor)

Citiraj ovu publikaciju

Habek, Mario; Brinar, Vesna; Borovečki, Fran
Genes associated with multiple sclerosis: 15 and counting // Expert review of molecular diagnostics, 10 (2010), 857-861 doi:10.1586/erm.10.77 (međunarodna recenzija, pregledni rad, znanstveni)
Habek, M., Brinar, V. & Borovečki, F. (2010) Genes associated with multiple sclerosis: 15 and counting. Expert review of molecular diagnostics, 10, 857-861 doi:10.1586/erm.10.77.
@article{article, year = {2010}, pages = {857-861}, DOI = {10.1586/erm.10.77}, keywords = {genetics, genome-wide association study, IL12A, MPHOSPH9/CDK2AP1, multiple sclerosis, RGS1}, journal = {Expert review of molecular diagnostics}, doi = {10.1586/erm.10.77}, volume = {10}, issn = {1473-7159}, title = {Genes associated with multiple sclerosis: 15 and counting}, keyword = {genetics, genome-wide association study, IL12A, MPHOSPH9/CDK2AP1, multiple sclerosis, RGS1} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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