Level of vascular endothelial growth factor in recurrent aphthous ulceration (CROSBI ID 476815)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Brozović-Sistig, Suzana ; Vučićević-Boras, Vanja ; Kleinheinz, Josef ; Joos, Uli ; Jukić, Silvana
engleski
Level of vascular endothelial growth factor in recurrent aphthous ulceration
Saliva contains biologically active proteins such as several different growth factors, cytokines and prostaglandins. This study investigated salivary level of vascular endothelial growth factor in 30 patients with minor and major recurrent aphthous ulceration (RAU) and 27 age matched healthy controls. VEGF was determined by ELISA in resting whole saliva of all participants. The development of recurrent aphthous ulceration was divided into stages: (1) early prodromal stage (mucosal redness or erosion), (2) active disease (frank ulceration) and (3) remission stage. Significantly lower level of salivary VEGF (p<0,001) was found in patients with major RAU during active disease when compared to the controls. Statistical analysis was done by Student t test. The mean ąSD were 327, 02ą113,05 pg/ml in acute stage of major RAU and 1488,88ą605,38 pg/ml in healthy controls. Salivary VEGF showed stage dependent alterations as well as variations regarding the type of ulcers. The VEGF concentration decreased significantly during the active stage of a disease and increased during the remission period in patients with major RAU. No differences in salivary VEGF in patients with acute minor RAU as well as during remission period when compared to controls was found. In conclusion, diminution of salivary VEGF was observed in acute stage of major RAU suggesting active involvement of this compound in the pathogenesis of the disease. It is also suggested that VEGF may also have cytoprotective role in homeostasis of oral cavity.
vascular endothelial factor; aphthous ulcers
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
228-x.
2000.
objavljeno
Podaci o matičnoj publikaciji
IADR CED/NEF
Academia Medica Varsoviensis
Varšava: Academia Medica Varsoviensis
Podaci o skupu
The 4th Joint Meeting of the IADR CED/NOF
poster
24.08.2000-27.08.2000
Varšava, Poljska