Heart rate variability during and after acute intermittent hypoxia in rats (CROSBI ID 578154)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Valic, Maja ; Valic, Zoran ; Pavlinac, Ivana ; Pecotic Renata ; Đogaš, Zoran
engleski
Heart rate variability during and after acute intermittent hypoxia in rats
Stimulation of breathing with acute intermittent hypoxia (AIH) elicits increases in respiratory and sympathetic outflow. Previous studies have shown that AIH produces increases in respiratory and sympathetic nerve activity that last long after hypoxic stimulation have ceased. Variability of heart rate (HR) from ECG recordings has been used as a non-invasive measure of cardiac autonomic modulation. This study was performed to investigate the HR variability in urethane-anesthetized, mechanically ventilated Sprague-Dawley rats exposed to five 3 minutes hypoxias. Blood pressure and ECG was monitored throughout the experiment and analyzed in the period during hypoxic exposures, 15, 30 and 60 minutes after the last hypoxic episode. Mean RR interval was 156.25 ms during baseline and did not significantly change throughout the experiment (151.72 ; 160.43 ; 161.91 and 157.77 ms, P=0.17). Low frequency (LF) component increased from 0.65 nu prior to hypoxia to 1.06 nu during the first hypoxic exposure and to 3.62 ; 9.46 and 1.79 nu at 15, 30 and 60 minutes after the last hypoxic episode, respectively (P=0.043). LF/HF ratio increased from 0.5 to 2.64 during the first hypoxic exposure and to 2.72 ; 6.15 and 6.9 nu at 15, 30 and 60 minutes after the last hypoxic episode, respectively (P=0.043). In time control experiments no change in HR variability was noted during the same time period observed. Conclusion: Heart rate variability shows significant changes during and after AIH protocol indicating the increase in sympathetic modulation of cardiac function during hypoxia and at the time after hypoxic exposures.
intermittent hypoxia; heart rate; rats
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
2011.
objavljeno
Podaci o matičnoj publikaciji
International Brain Research Organisation
Podaci o skupu
IBRO World Congress of Neuroscience
poster
01.01.2011-01.01.2011
Firenca, Italija