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Heart rate variability during and after acute intermittent hypoxia in rats (CROSBI ID 578154)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Valic, Maja ; Valic, Zoran ; Pavlinac, Ivana ; Pecotic Renata ; Đogaš, Zoran Heart rate variability during and after acute intermittent hypoxia in rats // International Brain Research Organisation. 2011

Podaci o odgovornosti

Valic, Maja ; Valic, Zoran ; Pavlinac, Ivana ; Pecotic Renata ; Đogaš, Zoran

engleski

Heart rate variability during and after acute intermittent hypoxia in rats

Stimulation of breathing with acute intermittent hypoxia (AIH) elicits increases in respiratory and sympathetic outflow. Previous studies have shown that AIH produces increases in respiratory and sympathetic nerve activity that last long after hypoxic stimulation have ceased. Variability of heart rate (HR) from ECG recordings has been used as a non-invasive measure of cardiac autonomic modulation. This study was performed to investigate the HR variability in urethane-anesthetized, mechanically ventilated Sprague-Dawley rats exposed to five 3 minutes hypoxias. Blood pressure and ECG was monitored throughout the experiment and analyzed in the period during hypoxic exposures, 15, 30 and 60 minutes after the last hypoxic episode. Mean RR interval was 156.25 ms during baseline and did not significantly change throughout the experiment (151.72 ; 160.43 ; 161.91 and 157.77 ms, P=0.17). Low frequency (LF) component increased from 0.65 nu prior to hypoxia to 1.06 nu during the first hypoxic exposure and to 3.62 ; 9.46 and 1.79 nu at 15, 30 and 60 minutes after the last hypoxic episode, respectively (P=0.043). LF/HF ratio increased from 0.5 to 2.64 during the first hypoxic exposure and to 2.72 ; 6.15 and 6.9 nu at 15, 30 and 60 minutes after the last hypoxic episode, respectively (P=0.043). In time control experiments no change in HR variability was noted during the same time period observed. Conclusion: Heart rate variability shows significant changes during and after AIH protocol indicating the increase in sympathetic modulation of cardiac function during hypoxia and at the time after hypoxic exposures.

intermittent hypoxia; heart rate; rats

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Podaci o prilogu

2011.

objavljeno

Podaci o matičnoj publikaciji

International Brain Research Organisation

Podaci o skupu

IBRO World Congress of Neuroscience

poster

01.01.2011-01.01.2011

Firenca, Italija

Povezanost rada

Temeljne medicinske znanosti