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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function


Artigas, M.S.; ...; Grković, Ivica; ...; Janković, Stipan; ...; Boban, Mladen; Boraska, Vesna; ...; Čurjurić, Ivan et al.
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function // Nature genetics, 43 (2011), 11; 1082-1090 doi:10.1038/ng.941 (međunarodna recenzija, članak, znanstveni)


Naslov
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Autori
Artigas, M.S. ; ... ; Grković, Ivica ; ... ; Janković, Stipan ; ... ; Boban, Mladen ; Boraska, Vesna ; ... ; Čurjurić, Ivan ; ... ; Kolčić, Ivana ; ... ; Polašek, Ozren ; ... ; Rudan, Igor ; ... ; Zgaga, Lina ; Zemunik, Tatijana

Izvornik
Nature genetics (1061-4036) 43 (2011), 11; 1082-1090

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Lung; gene; gwas

Sažetak
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48, 201 individuals of European ancestry with follow up of the top associations in up to an additional 46, 411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
108-1080315-0255 - Rizici za višekratne nesreće među ozlijeđenima na bolničkom liječenju (Ariana Vorko-Jović, )
216-1080315-0293 - Genetska epidemiologija šećerne bolesti tip 1 u populaciji Hrvatske (Tatijana Zemunik, )
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
HRZZ-PD-02.03/68 - Analiza i interpretacija cjelogenomskih studija povezanosti: primjena u projektu 10,001 Dalmatinac (Vesna Boraska, )

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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