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izvor podataka: crosbi

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function (CROSBI ID 175936)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Artigas, M.S. ; ... ; Grković, Ivica ; ... ; Janković, Stipan ; ... ; Boban, Mladen ; Boraska, Vesna ; ... ; Čurjurić, Ivan et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function // Nature genetics, 43 (2011), 11; 1082-1090. doi: 10.1038/ng.941

Podaci o odgovornosti

Artigas, M.S. ; ... ; Grković, Ivica ; ... ; Janković, Stipan ; ... ; Boban, Mladen ; Boraska, Vesna ; ... ; Čurjurić, Ivan ; ... ; Kolčić, Ivana ; ... ; Polašek, Ozren ; ... ; Rudan, Igor ; ... ; Zgaga, Lina ; Zemunik, Tatijana

engleski

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48, 201 individuals of European ancestry with follow up of the top associations in up to an additional 46, 411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

lung; gene; gwas

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Podaci o izdanju

43 (11)

2011.

1082-1090

objavljeno

1061-4036

10.1038/ng.941

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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