engleski

The risk of hematopoetic malignancy in children born after in vitro fertilisation

The risk of hematopoetic malignancy in children born after in vitro fertilisation. Abstract: Infertility is one of the major health and social problems where assisted reproductive technology such as in vitro fertilization (IVF) can offer an efficient solution. Evaluation of children conceived by IVF is neccessary to determine the safety of the method. Hematopoetic tumors (leukemia and lymphoma) are the most common childhood cancers. Some study found an association with IVF and increased risk for acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) in children. Aim: The aim of present study was to determine whether there is an increased risk for hematopoetic tumors in children conceived by IVF in comparison to children born after natural conception. Patients and methods: The study included 550 children treated for leukemia or lymphoma (345 ALL, 67 acute myeloblastic leukemia (AML), 63 Hodgkin lymphoma and 75 NHL) in the Department of Pediatric, University of Zagreb, School of Medicine Zagreb, Croatia, between 1994. and 2009.y. Results: Three children of 550 included in the study were born after IVF. Two suffered from ALL and one from AML. Conclusion: Results of our study showed no increased risk for childhood leukemia and lymphoma in children conceived by IVF in comparison to children conceived naturally. The main limitation of our, and most of other similar studies was the sample size not large enough to decline the discrepancy of literature data and to provide an unambiguous answer to the question of increased risk of hematopoetic tumors in children concieved by IVF.

malignancy ; in vitro fertilisation

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