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Genotyping of Bacillus anthracis isolated from Croatia and Bosnia and Herzegovina

Anthrax is a serious disease caused by Bacillus anthracis. Humans can become infected by handling products from infected animals, by breathing spores and rarely by eating undercooked meat from infected animals. The genome of B. anthracis is highly monomorphic, and thus shows very low DNA sequence variation. We analyzed the molecular characteristics of 12 Bacillus anthracis isolates from outbreaks in Croatia and Bosnia and Herzegovina that have occurred during the past ten years along with two vaccine strains. Genoyping system based on variable-number tandem repeat analysis at six loci revealed that six isolates belong to genotype from the A1.a cluster while six isolates relate to the B2 cluster, compared to 89 previously described genotypes. The distribution of two evolutionarily distant clusters suggests an introduction of B. anthracis to this area in at least two separate events.

Bacillus anthracis; genotyping; Croatia and Bosnia and Herzegovina

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