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Pregled bibliografske jedinice broj: 536181

Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma


Ulamec, Monika; Džombeta, Tihana; Čupić, Hrvoje; Leniček, Tanja; Tomas, Davor; Krušlin, Božo
Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma // Pathology oncology research, 18 (2012), 2; 365-370 doi:10.1007/s12253-011-9453-0 (međunarodna recenzija, članak, znanstveni)


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Naslov
Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma

Autori
Ulamec, Monika ; Džombeta, Tihana ; Čupić, Hrvoje ; Leniček, Tanja ; Tomas, Davor ; Krušlin, Božo

Izvornik
Pathology oncology research (1219-4956) 18 (2012), 2; 365-370

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
periacinar retraction clefting; prostatic adenocarcinoma; expression in prostatic adenocarcinoma; D2 4; lymphovascular invasion; retraction clefting

Sažetak
Abstract Retraction clefting is known to appear in various types of tumors, but it has only recently been recognized as a specific histological phenomenon. Previously, it was considered merely a laboratory procedure artifact, but lately, there have been some assumptions that peritumoral retractions actually represent lymphatic spaces. In our study, we analyzed neoplastic glands in 52 specimens of prostatic adenocarcinoma. Immunohistochemical analysis was performed using D2-40 antibody, to highlight lymphatic endothelium and thereby differentiate actual lymph vessels or lymphovascular invasion from periacinar retractions. Our results showed that the number of lymph vessels was significantly lower in tumorous tissue compared to adjacent normal prostatic tissue. On the other hand, the number of lymph vessels in tumorous tissue was significantly higher than the number of lymph vessels mimicking periacinar retractions. Overall, the number of lymph vessels mimicking periacinar clefts was particularly low. These results are in accordance with our previous studies, which had shown that periacinar clefting appears due to lack of basal cells and stromal changes around tumorous acini. Also, these results support our hypothesis that retractions do not represent lymph vessels but should be considered a distinct entity, which is proven to be helpful both as diagnostic and predictive factor.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-1081870-1884 - Razvojna neuropatologija genetskih malformacija moždane kore čovjeka (Krušlin, Božo, MZOS ) ( POIROT)
134-0000000-3381 - Promjene bubrežne arterije u bolesnika s karcinomom bubrega (Čupić, Hrvoje, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Poveznice na cjeloviti tekst rada:

doi www.springerlink.com

Citiraj ovu publikaciju:

Ulamec, Monika; Džombeta, Tihana; Čupić, Hrvoje; Leniček, Tanja; Tomas, Davor; Krušlin, Božo
Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma // Pathology oncology research, 18 (2012), 2; 365-370 doi:10.1007/s12253-011-9453-0 (međunarodna recenzija, članak, znanstveni)
Ulamec, M., Džombeta, T., Čupić, H., Leniček, T., Tomas, D. & Krušlin, B. (2012) Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma. Pathology oncology research, 18 (2), 365-370 doi:10.1007/s12253-011-9453-0.
@article{article, year = {2012}, pages = {365-370}, DOI = {10.1007/s12253-011-9453-0}, keywords = {periacinar retraction clefting, prostatic adenocarcinoma, expression in prostatic adenocarcinoma, D2 4, lymphovascular invasion, retraction clefting}, journal = {Pathology oncology research}, doi = {10.1007/s12253-011-9453-0}, volume = {18}, number = {2}, issn = {1219-4956}, title = {Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma}, keyword = {periacinar retraction clefting, prostatic adenocarcinoma, expression in prostatic adenocarcinoma, D2 4, lymphovascular invasion, retraction clefting} }
@article{article, year = {2012}, pages = {365-370}, DOI = {10.1007/s12253-011-9453-0}, keywords = {periacinar retraction clefting, prostatic adenocarcinoma, expression in prostatic adenocarcinoma, D2 4, lymphovascular invasion, retraction clefting}, journal = {Pathology oncology research}, doi = {10.1007/s12253-011-9453-0}, volume = {18}, number = {2}, issn = {1219-4956}, title = {Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma}, keyword = {periacinar retraction clefting, prostatic adenocarcinoma, expression in prostatic adenocarcinoma, D2 4, lymphovascular invasion, retraction clefting} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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