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Pregled bibliografske jedinice broj: 536047

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure


Wain L.V.; ...; Polašek, Ozren; Boban, Mladen; ...; Rudan, Igor; ...; van Duijn, Cornelia M.
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure // Nature genetics, 43 (2011), 10; 1005-1011 doi:10.1038/ng.922 (međunarodna recenzija, pismo, znanstveni)


Naslov
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Autori
Wain L.V. ; ... ; Polašek, Ozren ; Boban, Mladen ; ... ; Rudan, Igor ; ... ; van Duijn, Cornelia M.

Izvornik
Nature genetics (1061-4036) 43 (2011), 10; 1005-1011

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
Pulse pressure; mean arterial pressure; genome-wide

Sažetak
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74, 064) and follow-up studies (N = 48, 607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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