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Pregled bibliografske jedinice broj: 535537

Application of dosimetry systems and cytogenetic status of the child population exposed to diagnostic X-rays by use of the cytokinesis-block micronucleus cytome assay


Gajski, Goran; Milković, Đurđica; Ranogajec-Komor, Maria; Miljanić, Saveta; Garaj-Vrhovac, Vera
Application of dosimetry systems and cytogenetic status of the child population exposed to diagnostic X-rays by use of the cytokinesis-block micronucleus cytome assay // JAT. Journal of applied toxicology, 31 (2011), 7; 608-617 doi:10.1002/jat.1603 (međunarodna recenzija, članak, znanstveni)


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Naslov
Application of dosimetry systems and cytogenetic status of the child population exposed to diagnostic X-rays by use of the cytokinesis-block micronucleus cytome assay

Autori
Gajski, Goran ; Milković, Đurđica ; Ranogajec-Komor, Maria ; Miljanić, Saveta ; Garaj-Vrhovac, Vera

Izvornik
JAT. Journal of applied toxicology (0260-437X) 31 (2011), 7; 608-617

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
X-ray dosimetry; absorbed dose; children; chromosomal damage; peripheral blood lymphocytes; micronucleus cytome assay; ALARA

Sažetak
Low-dose ionizing radiation used for medical purposes is one of the definite risk factors for cancer development, and children exposed to ionizing radiation are at a relatively greater cancer risk as they have more rapidly dividing cells than adults and have longer life expectancy. Since cytokinesis-block micronucleus cytome (CBMN Cyt) assay has become one of the standard endpoints for radiation biological dosimetry, we used that assay in the present work for the assessment of different types of chromosomal damage in children exposed to diagnostic X-ray procedures. Twenty children all with pulmonary diseases between the ages of 4 and 14 years (11.30 ± 2.74) were evaluated. Absorbed dose measurements were conducted for posterior-anterior projection on the forehead, thyroid gland, gonads, chest and back. Doses were measured using thermoluminescence and radiophotoluminescent dosimetry systems. It was shown that, after diagnostic X-rays, the mean total number of CBMN Cyt assay parameters (micronucleus, nucleoplasmic bridges and nuclear buds) was significantly higher than prior to diagnostic procedure and that interindividual differences existed for each monitored child. For the nuclear division index counted prior and after examination, no significant differences were noted among mean group values. These data suggest that even low-dose diagnostic X-ray exposure may induce damaging effect in the somatic DNA of exposed children, indicating that immense care should be given in both minimizing and optimizing radiation exposure to diminish the radiation burden, especially in the youngest population.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
022-0222148-2125 - Mutageni i antimutageni u ekogenetičkim istraživanjima (Garaj-Vrhovac, Vera, MZOS ) ( POIROT)
098-0982904-2954 - Fizičko-kemijski učinci ionizirajućih zračenja u materijalima (Mihaljević, Branka, MZOS ) ( POIROT)
277-2770966-0962 - Učinci radioloških dijagnostičkih postupaka pri pregledu dišnih putova u djece (Milković, Đurđica, MZOS ) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Dječja bolnica Srebrnjak

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Gajski, Goran; Milković, Đurđica; Ranogajec-Komor, Maria; Miljanić, Saveta; Garaj-Vrhovac, Vera
Application of dosimetry systems and cytogenetic status of the child population exposed to diagnostic X-rays by use of the cytokinesis-block micronucleus cytome assay // JAT. Journal of applied toxicology, 31 (2011), 7; 608-617 doi:10.1002/jat.1603 (međunarodna recenzija, članak, znanstveni)
Gajski, G., Milković, Đ., Ranogajec-Komor, M., Miljanić, S. & Garaj-Vrhovac, V. (2011) Application of dosimetry systems and cytogenetic status of the child population exposed to diagnostic X-rays by use of the cytokinesis-block micronucleus cytome assay. JAT. Journal of applied toxicology, 31 (7), 608-617 doi:10.1002/jat.1603.
@article{article, author = {Gajski, Goran and Milkovi\'{c}, \DJur\djica and Ranogajec-Komor, Maria and Miljani\'{c}, Saveta and Garaj-Vrhovac, Vera}, year = {2011}, pages = {608-617}, DOI = {10.1002/jat.1603}, keywords = {X-ray dosimetry, absorbed dose, children, chromosomal damage, peripheral blood lymphocytes, micronucleus cytome assay, ALARA}, journal = {JAT. Journal of applied toxicology}, doi = {10.1002/jat.1603}, volume = {31}, number = {7}, issn = {0260-437X}, title = {Application of dosimetry systems and cytogenetic status of the child population exposed to diagnostic X-rays by use of the cytokinesis-block micronucleus cytome assay}, keyword = {X-ray dosimetry, absorbed dose, children, chromosomal damage, peripheral blood lymphocytes, micronucleus cytome assay, ALARA} }
@article{article, author = {Gajski, Goran and Milkovi\'{c}, \DJur\djica and Ranogajec-Komor, Maria and Miljani\'{c}, Saveta and Garaj-Vrhovac, Vera}, year = {2011}, pages = {608-617}, DOI = {10.1002/jat.1603}, keywords = {X-ray dosimetry, absorbed dose, children, chromosomal damage, peripheral blood lymphocytes, micronucleus cytome assay, ALARA}, journal = {JAT. Journal of applied toxicology}, doi = {10.1002/jat.1603}, volume = {31}, number = {7}, issn = {0260-437X}, title = {Application of dosimetry systems and cytogenetic status of the child population exposed to diagnostic X-rays by use of the cytokinesis-block micronucleus cytome assay}, keyword = {X-ray dosimetry, absorbed dose, children, chromosomal damage, peripheral blood lymphocytes, micronucleus cytome assay, ALARA} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • Toxicology Abstracts
  • Scopus


Citati:





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