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Pregled bibliografske jedinice broj: 535163

Concentrations of GH, IGF-1 and insulin in CSF of healthy people


Bilić, Ervina; Bilić, Ernest; Kušec, Vesna; Zibar, Karin; Čerimagić, Denis; Konjevoda, Paško; Tripković, Branko; Delimar, Domagoj; Žagar, Marija
Concentrations of GH, IGF-1 and insulin in CSF of healthy people // Neurologia Croatica, 60 (2011), 2; 73-81 (međunarodna recenzija, članak, znanstveni)


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Naslov
Concentrations of GH, IGF-1 and insulin in CSF of healthy people

Autori
Bilić, Ervina ; Bilić, Ernest ; Kušec, Vesna ; Zibar, Karin ; Čerimagić, Denis ; Konjevoda, Paško ; Tripković, Branko ; Delimar, Domagoj ; Žagar, Marija

Izvornik
Neurologia Croatica (0353-8842) 60 (2011), 2; 73-81

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GH ; IGF-1 ; insulin

Sažetak
Growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin are involved in brain development, and also act as neuroprotective factors. The values of these hormones in healthy population have not been published so far. We measured concentrations of GH, IGF-1 and insulin in cerebrospinal fluid (CSF) of 57 healthy people (35 male and 22 female), undergoing lumbar puncture for spinal anesthesia before surgery of the knee joint. In men, the mean (SD ; min-max) concentrations of GH, IGF-1 and insulin in CSF were 0.67 (0.11 ; 0.50-0.90) µU/mL ; 7.49 (0.92 ; 6.00-9.00) µg/L and 0.71 (0.13 ; 0.40-0.90) µU/mL, respectively. In women, the mean CSF concentrations of GH, IGF-1 and insulin were 0.69 (0.10 ; 0.50-0.90) µU/mL ; 7.32 (0.95 ; 6.00-9.00) µg/L and 0.68 (0.13 ; 0.40-0.90) µU/mL, respectively. None of the study hormones showed statistically significant sex difference. There were no significant bivariate correlation between GH, IGF-1 and insulin. The hormones did not correlate with age either. Determination of the normal range of GH, IGF-1 and insulin in CSF could help identify deviations in CSF hormone status in particular neurologic diseases. These values could prove important in the screening, diagnosis and management of various diseases involving the central nervous system.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
MZOS-108-1080315-0297 - Odrednice i rana dijagnoza bolesti motoričkih neurona u populaciji Hrvatske (Bilić, Ervina, MZOS ) ( POIROT)
MZOS-108-1080399-0383 - Muški i ženski spolni sustav: razvoj, normalna histofiziologija i neplodnost (Ježek, Davor, MZOS ) ( POIROT)
MZOS-214-1080229-0163 - Zajednička molekularna osnova etiopatogeneza koštanih poremećaja u ljudi (Kušec, Vesna, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Opća bolnica Dubrovnik

Poveznice na cjeloviti tekst rada:

neurologiacroatica.com

Citiraj ovu publikaciju:

Bilić, Ervina; Bilić, Ernest; Kušec, Vesna; Zibar, Karin; Čerimagić, Denis; Konjevoda, Paško; Tripković, Branko; Delimar, Domagoj; Žagar, Marija
Concentrations of GH, IGF-1 and insulin in CSF of healthy people // Neurologia Croatica, 60 (2011), 2; 73-81 (međunarodna recenzija, članak, znanstveni)
Bilić, E., Bilić, E., Kušec, V., Zibar, K., Čerimagić, D., Konjevoda, P., Tripković, B., Delimar, D. & Žagar, M. (2011) Concentrations of GH, IGF-1 and insulin in CSF of healthy people. Neurologia Croatica, 60 (2), 73-81.
@article{article, year = {2011}, pages = {73-81}, keywords = {GH, IGF-1, insulin}, journal = {Neurologia Croatica}, volume = {60}, number = {2}, issn = {0353-8842}, title = {Concentrations of GH, IGF-1 and insulin in CSF of healthy people}, keyword = {GH, IGF-1, insulin} }
@article{article, year = {2011}, pages = {73-81}, keywords = {GH, IGF-1, insulin}, journal = {Neurologia Croatica}, volume = {60}, number = {2}, issn = {0353-8842}, title = {Concentrations of GH, IGF-1 and insulin in CSF of healthy people}, keyword = {GH, IGF-1, insulin} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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