Comparative randomized pilot study of azithromycin and doxycycline efficacy in the treatment of prostate infection caused by Chlamydia trachomatis (CROSBI ID 175379)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Škerk, Višnja ; Krhen, Ivan ; Lisić, Miroslav ; Roglić, Srđan, Škerk, Vedrana ; Ljubin-Sternak, Sunćanica ; Banaszak, A ; Strugar-Šuica, J.
engleski
Comparative randomized pilot study of azithromycin and doxycycline efficacy in the treatment of prostate infection caused by Chlamydia trachomatis
The study included 125 adult patients (>18years of age) who had symptoms of chronic prostatitis and proven presence of Chlamydia trachomatis. The presence of C. trachomatis was confirmed in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage by a DNA/RNA hybridization method and/or by isolation on McCoy culture and then by immunofluorescent typing with monoclonal antibodies. The patients were randomized in the ratio 2/1 ; azithromycin/doxycycline, to receive a total of 4.0 g azithromycin over 4 weeks, given as a single dose of 1 X 1000 mg weekly for 4 weeks or doxycycline 100 mg b.i.d. for 28 days. Patients' sexual partners were treated at the same time. Clinical and bacteriological efficacy was evaluated 4-6 weeks after the end of therapy. In the group of patients with chlamydial infection of the prostate, there was no significant difference between the eradication rates (azithromycin 65/82, doxycycline 33/43 ; P = 0.82) and the clinical cure rates (azithromycin 56/82, doxycycline 30/43 ; P = 0.94) of the two antimicrobials.
prostatitis ; Chlamydia trachomatis ; azithromycin ; doxycycline
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
24 (2)
2004.
188-191
objavljeno
0924-8579
10.1016/j.ijantimicag.2004.03.014
Povezanost rada
Kliničke medicinske znanosti