engleski

Transition of epiglottal epithelium during human development

Our previous results have shown that human epiglottal epithelium changes during development, from single-layered squamous epithelium in the 6-week-old embryo to two-layered cuboidal epithelium in the early 8-week-old embryo ; in the newborn, pseudostratified epithelium with goblet cells predominates and after the air-flow is established, stratified squamous epithelium predominates. Seven-week-old and 9-week-old embryo epiglottal epithelium was now analyzed in more detail and compared. Embryos from the celloidin collection of human embryos belonging to the Archive of the Department of Histology and Embryology were stained by HE, Azan, Masson trichrome stain, Verhoeff iron hematoxylin and PAF-Halmi. Epiglottal epithelia were investigated by light microscopy. In the 6-week-old embryo, epiglottal swelling was covered by a single layer of cuboidal cells. In the 7-week-old embryo, two-layered cuboidal epithelium was discovered. In 9-week-old fetus, epiglottal epithelium was multilayered columnar without cilia and goblet cells. It has now been confirmed that single-layered epiglottal epithelium has changed to the two-layered epithelium already in the 7-week-old embryo. Developmental studies like this one might be of importance for tissue engineering purposes.

epiglottis ; human ; development

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