engleski

Serum levels of cytokines in depressed patients with or without suicidal behaviour

Background. Patients with depression have been found to exhibit increased peripheral inflammatory cytokines, and several studies indicated that antidepressant decreased the production of IL-6 and TNFα. Methods The subjects were depressed patients (N=86) with attempted suicide ( N=35, age X=49y, SD= 15, 6 , M/F =11/16), those with no suicidal behavior (N=51, age X=51y, SD=12, 9 , M/F=34/59 ), all admitted in the Sveti Ivan Psychiatric Hospital, while the control group was made of voluntary blood donors (N=92, age X=49, SD=11, 6, M/F=48/51). Depressed patients were treated with SSRI (36/86) or other tricyclic and heterocyclic antidepressants (50/86). The IL-6 and TNFα concentration was determined using a competitive enzyme immunoassay test (BioSorce, Belgium) on the Elysis Uno immunoanalyser (Human, Germany). Results There are no differences in IL-6 (Kruskal-Wallis test, p=0.079) and TNFα (ANOVA, p=0.469) concentration between depressed patients with or without suicidal behaviour and control group. The concentration of IL-6 was significantly higher in depressive suicidal patients without SSRI therapy (median 31 pg/ml, 95%CI 22-88) compared to non suicidal depressed patients either with or without SSRI therapy (median 21 pg/ml, 95%CI 16-3, p=0, 046 ; median 18 pg/ml, 95%CI 12-24, p=0, 005, respectively). There are no differences in TNFα concentration regarding antidepressive therapy in those patients. Conclusion Translational implication of these findings includes opportunity to identify relevant patients populations and monitor therapeutic efficacy with various antidepressive agents, including SSRIs, tricyclic and heterocyclic antidepressants, at the level of the immune system in addition to behavior.

cytokines; depression; attempted suicide

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