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Pregled bibliografske jedinice broj: 532492

5-azacytidine enhances proliferation in transplanted rat fetal epiglottis


Marinović-Kulišić, Sandra; Jurić-Lekić, Gordana; Vikić-Topić, Maša; Lokošek, Vedran; Radujković, Vedran, Bulić-Jakuš, Floriana; Katušić, Ana; Vlahović, Maja; Šerman, Ljiljana; Sinčić, Nino
5-azacytidine enhances proliferation in transplanted rat fetal epiglottis // Frontiers in bioscience, E3 (2011), 2; 581-590 doi:10.2741/e271 (međunarodna recenzija, članak, znanstveni)


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Naslov
5-azacytidine enhances proliferation in transplanted rat fetal epiglottis

Autori
Marinović-Kulišić, Sandra ; Jurić-Lekić, Gordana ; Vikić-Topić, Maša ; Lokošek, Vedran ; Radujković, Vedran, Bulić-Jakuš, Floriana ; Katušić, Ana ; Vlahović, Maja ; Šerman, Ljiljana ; Sinčić, Nino

Izvornik
Frontiers in bioscience (1093-9946) E3 (2011), 2; 581-590

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rat epiglottis; 5-azacytidine; PCNA

Sažetak
Fetal rat epiglottis and its developmental potential in ectopic transplants under the influence of the epigenetic drug was investigated. Epiglottises from 17-days-old rat embryos were transplanted under kidney capsules of adult rats for 14 days. 5-azacytidine (5 mg/kg) was injected intraperitoneally during first three days and controls were sham treated. TEM, immunohistochemical detection and quantitative stereological analysis of the Proliferating Cell Nuclear Antigen (PCNA) expression (numerical density N(v)) were performed. Typical chondroblasts with long surface processes and sparse lipid droplets were found in fetal epiglottis and chondrocytes with shorter processes, numerous lipid droplets and elastic fibers in adult. PCNA was expressed in almost all cells of the fetal epiglottis while in the adult it was expressed in minority of cells. In transplants, differentiation progressed towards the differentiation found in the adult. Application of 5-azacytidine increased the capacity for proliferation (N(v PCNA)) in comparison to controls but no difference in differentiation was observed. Data about the developmental potential and induction of proliferation in mammalian epiglottis by epigenetic modulation is of importance for regenerative medicine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080399-0335 - Eksperimentalni embrionalni tumori i razvoj zametaka sisavaca in vitro i in vivo (Jakuš, Florijana, MZOS ) ( POIROT)
108-1080399-0383 - Muški i ženski spolni sustav: razvoj, normalna histofiziologija i neplodnost (Ježek, Davor, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Marinović-Kulišić, Sandra; Jurić-Lekić, Gordana; Vikić-Topić, Maša; Lokošek, Vedran; Radujković, Vedran, Bulić-Jakuš, Floriana; Katušić, Ana; Vlahović, Maja; Šerman, Ljiljana; Sinčić, Nino
5-azacytidine enhances proliferation in transplanted rat fetal epiglottis // Frontiers in bioscience, E3 (2011), 2; 581-590 doi:10.2741/e271 (međunarodna recenzija, članak, znanstveni)
Marinović-Kulišić, S., Jurić-Lekić, G., Vikić-Topić, M., Lokošek, V., Radujković, Vedran, Bulić-Jakuš, Floriana, Katušić, A., Vlahović, M., Šerman, L. & Sinčić, N. (2011) 5-azacytidine enhances proliferation in transplanted rat fetal epiglottis. Frontiers in bioscience, E3 (2), 581-590 doi:10.2741/e271.
@article{article, year = {2011}, pages = {581-590}, DOI = {10.2741/e271}, keywords = {rat epiglottis, 5-azacytidine, PCNA}, journal = {Frontiers in bioscience}, doi = {10.2741/e271}, volume = {E3}, number = {2}, issn = {1093-9946}, title = {5-azacytidine enhances proliferation in transplanted rat fetal epiglottis}, keyword = {rat epiglottis, 5-azacytidine, PCNA} }
@article{article, year = {2011}, pages = {581-590}, DOI = {10.2741/e271}, keywords = {rat epiglottis, 5-azacytidine, PCNA}, journal = {Frontiers in bioscience}, doi = {10.2741/e271}, volume = {E3}, number = {2}, issn = {1093-9946}, title = {5-azacytidine enhances proliferation in transplanted rat fetal epiglottis}, keyword = {rat epiglottis, 5-azacytidine, PCNA} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • MEDLINE
  • PubMrf


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