engleski

Start/stop codon-like trinucleotides (CLTs) and extended clusters as new language of DNA

We introduce the extended start/stop codon-like trinucleotides (CLTs) for noncoding DNA sequences, based on trinucleotide cluster extension, generated by specific single-nucleotide multiplications. Extended cluster analysis gives rise to rich information potential as a new language of DNA ("CLT language"). The analysis of start/stop CLTs extended clusters provides qualitative and quantitative differentiation and characterization of alpha satellites, as well as of other repetitive and non-repetitive noncoding sequences. As a measure of CLT extension of DNA sequences the extension factor r is introduced. Start/stop CLTs enable a distinction of three segments within alpha satellite, the first and the second as wrapping sequences and the third as a linker. Within a linker there are no start/stop CLTs. On the basis of start/stop CLTs, it is hypothesized that these noncoding sequences may be involved in the network of gene regulators.

alpha satellites; start/stop codons; nucleosome; cluster extension; gene regulators

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