engleski

Synthesis of thiadizine with the coumarine core as a potential growth inhibitor of some mycotoxigen moulds

The coumarine derivatives (2H-chromen-2-ones) are heterocyclic compounds, many of whom have significant biological activities. They contain 2-pyrone core that is condensed with the benzen ring. They can mostly be found in herbal species.Coumarine core based compounds are very useful in medicine, food and pharmaceutical industry, due to its specific inhibitory effects on the growth of specific microorganisms. This paper focuses special attention on the design and synthesis of the new thiadiazine from substitued coumarine thisemicarbazides. Thiadizine are also biologicly active compounds with antiviral, antitumor, antituberculosis and other effects. By reacting the condensed 3--bromoacetylcoumarine with the matching thiosemicarbazides, there were some varieties of thiadiazine created that have not been described in literature. The reaction progress was monitored with a thin layer chromotography, the attained compounds were purified by recrystallization and the specific points of melting, as well as their composition, were determined. The structure of particular compounds was confirmed with 1H-NMR i IR spectrometry, as well as with mass spectrometry.

coumarine; thiadiazine; thiosemicarbazide; biological activity; mycotoxine

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