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Pregled bibliografske jedinice broj: 529221

Correlation of Endothelin-1 mRNA Expression and Bone Structure in Advanced Osteoarthritis


Vukelić, Lucian; Šoša, Ivan; Cvijanović, Olga; Mađarević, Tomislav; Jotanović, Zdravko; Vukelić Šarunić, Alenka; Štifter, Sanja; Zoričić Cvek, Sanja; Đudarić, Luka; Šestan, Branko; Bobinac, Dragica
Correlation of Endothelin-1 mRNA Expression and Bone Structure in Advanced Osteoarthritis // Medical hypotheses, 77 (2011), 5; 927-929 doi:10.1016/j.mehy.2011.08.015 (međunarodna recenzija, članak, znanstveni)


Naslov
Correlation of Endothelin-1 mRNA Expression and Bone Structure in Advanced Osteoarthritis

Autori
Vukelić, Lucian ; Šoša, Ivan ; Cvijanović, Olga ; Mađarević, Tomislav ; Jotanović, Zdravko ; Vukelić Šarunić, Alenka ; Štifter, Sanja ; Zoričić Cvek, Sanja ; Đudarić, Luka ; Šestan, Branko ; Bobinac, Dragica

Izvornik
Medical hypotheses (0306-9877) 77 (2011), 5; 927-929

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bone; articular cartilage; endothelin-1; osteoarthritis

Sažetak
Recent understandings of the vascular contribution of pathophysiology of osteoarthritis (OA) mount new evidence of cross-talking between subchondral bone tissue and articular cartilage that might have a decisive role in a pathophysiology of Osteoarthritis (OA). These understandings include blood flow (or interstitial fluid) impairment in subchondral bone. With regard to the mentioned role of the vasculature, the absence of custom nourishing to articular cartilage, and established, vasoconstrictive role of endothelin-1 (ET-1) it was reasonable to assume that ET-1 has an inconvertible role in pathophysiology of OA. Another moment in pathophysiology of OA is apoptosis of subchondral osteocytes, what induces osteoclastic resorption and at least temporarily reduces the bony support for the overlying cartilage. Since regional dependence of this protein's expression was presumed, we suggest a regional division of subchondral bone by histomorphometrical analysis and quantification of identified protein by Real Time Polymerase Chain Reaction Analysis (RT-PCR). Obtained results should be compared to serum levels of soluble ET-1, what would enforce this methods validity. Herewith, a new screening marker of patients with osteoarthritis would be established. This would enable detection and follow-up of groups threatened by this, growing, cause of disability and decreased quality of life.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-0073 - Sudsko-medicinske i toksikološke značajke samoubojstava u Republici Hrvatskoj (Alan Bosnar, )
062-0000000-3559 - Uloga koštanih morfogenih proteina i inhibitora u nastanku osteofita čovjeka (Sanja Zoričić Cvek, )
062-0620226-0207 - Promjene koštanog metabolizma u bolestima bubrega i jetre (Dragica Bobinac, )

Ustanove
Medicinski fakultet, Rijeka,
Klinika za ortopediju Lovran,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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