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Genotoksični učinak preparata za izbjeljivanje zubi na oralnu sluznicu


Klarić, Eva; Par, Matej; Profeta, Ivona; Kopjar, Nevenka; Želježić, Davor; Kašuba, Vilena; Rozgaj, Ružica; Tarle, Zrinka
Genotoksični učinak preparata za izbjeljivanje zubi na oralnu sluznicu // CED-2011-Abstract book
Budimpešta, Mađarska, 2011. str. - (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Genotoksični učinak preparata za izbjeljivanje zubi na oralnu sluznicu
(Genotoxic effect of two bleaching agents on the oral mucosa)

Autori
Klarić, Eva ; Par, Matej ; Profeta, Ivona ; Kopjar, Nevenka ; Želježić, Davor ; Kašuba, Vilena ; Rozgaj, Ružica ; Tarle, Zrinka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
CED-2011-Abstract book / - , 2011

Skup
CED IADR

Mjesto i datum
Budimpešta, Mađarska, 31.08.2011-03.09.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Izbjeljivanje zubi ; vodikov peroksid ; test genotoksičnosti ; mikronukleus test
(Tooth bleaching ; hydrogen peroxide ; genotoxicity test ; micronucleus test)

Sažetak
Background: Genotoxicity of hydrogen peroxide is the result of free radical formation which can damage intracellular structures. The purpose was to investigate a possible genotoxic effect of two bleaching products. Methods: The research was conducted on 21 subjects divided into two groups. Group 1 used Zoom2 and group 2 Opalescence Boost bleaching agent. Specimens of the gingival area and the upper lip mucosa were taken just before, immediately after and 72 hours after the procedure and were analyzed using micronucleus test. Results: 72 hours after bleaching samples collected from the gingiva (Zoom2) and lip and gingiva (Boost) showed statistically significant increase (p<0.05) of the total number of MN while samples from gingiva (Boost) had increase of number of cells with 3+ MN. Lip samples (Zoom2) showed no increase of genotoxicity markers. Conclusion: Both preparations showed the potential genotoxic effect. Bleaching can affect the genome of mucosal cells to a certain extent, but it is difficult to assess clinical significance of these findings. Clinical implications: Statistically significant increase of genotoxicity markers were relatively small in amount and since oral mucosa cells have short lifespan, one-time exposure to mild genotoxic noxa probably has negligible carcinogenic potential. Key words: tooth bleaching, hydrogen peroxide, genotoxicity test, micronucleus test.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina



POVEZANOST RADA


Projekt / tema
065-0352851-0410 - Nanostruktura restaurativnih materijala i interakcije s tvrdim zubnim tkivima (Zrinka Tarle, )

Ustanove
Stomatološki fakultet, Zagreb