engleski

Effect of Gastric Pentadecapeptide BPC-157on Reflux Laryngitis in Rat Animal Model of GERD

Extraesophageal GERD complications, such as reflux laryngitis, develop when some of acidic refluxate in the proximal esophagus enters the lower or upper airways. The aim of the study was to evaluate the effect of gastric pentadecapeptide BPC-157 therapy on rats with reflux laryngitis. The study was done on fifty adult female Wistar rats and they were randomy assigned into five groups, four experimental groups treated with 10 mcg/kg and 10 ng/kg pentadecapeptide BPC-157, intraperitonealy and intragastricaly) and control (treated with 0, 9% saline). The patohistologic and macroscopic grades of the laryngeal mucosa of treated animals, for both concentrations (10 mcg/kg an 10 ng/kg), were significantly better than that in the control (p(5). The result suggest that the gastric pentadecapeptide BPC-157 may have protectiv effect on reflux laryngitis in gastroesophageal reflux disease.

BPC-157 ; reflux laryngitis ; extraesophageal GERD

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