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Effect of Gastric Pentadecapeptide BPC-157on Reflux Laryngitis in Rat Animal Model of GERD


Drviš, Petar; Bedeković, Vladimir; Kalogjera, Livio; Shejbal, Dražen; Petrović, Igor; Dobrić, Ivan; Kopljar, Mario; Kokić, Neven; Seiwerth, Sven; Sikirić, Predrag
Effect of Gastric Pentadecapeptide BPC-157on Reflux Laryngitis in Rat Animal Model of GERD // 11th International Conference on Ulcer Research : proceedings / Sikirić, Predrag ; Seiverth, Sven, Mozsik Gyula ; Arakawa, Tetsuo ; Takeuchi, Koji (ur.).
Bologna: Medimond S. r. l., 2003. str. 27-30 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
Effect of Gastric Pentadecapeptide BPC-157on Reflux Laryngitis in Rat Animal Model of GERD

Autori
Drviš, Petar ; Bedeković, Vladimir ; Kalogjera, Livio ; Shejbal, Dražen ; Petrović, Igor ; Dobrić, Ivan ; Kopljar, Mario ; Kokić, Neven ; Seiwerth, Sven ; Sikirić, Predrag

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
11th International Conference on Ulcer Research : proceedings / Sikirić, Predrag ; Seiverth, Sven, Mozsik Gyula ; Arakawa, Tetsuo ; Takeuchi, Koji - Bologna : Medimond S. r. l., 2003, 27-30

ISBN
88-7587-021-7

Skup
International Conference on Ulcer Research (11 ; 2003)

Mjesto i datum
Dubrovnik, Republika Hrvatska, 15.-20.09.2003

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BPC-157; reflux laryngitis; extraesophageal GERD

Sažetak
Extraesophageal GERD complications, such as reflux laryngitis, develop when some of acidic refluxate in the proximal esophagus enters the lower or upper airways. The aim of the study was to evaluate the effect of gastric pentadecapeptide BPC-157 therapy on rats with reflux laryngitis. The study was done on fifty adult female Wistar rats and they were randomy assigned into five groups, four experimental groups treated with 10 mcg/kg and 10 ng/kg pentadecapeptide BPC-157, intraperitonealy and intragastricaly) and control (treated with 0, 9% saline). The patohistologic and macroscopic grades of the laryngeal mucosa of treated animals, for both concentrations (10 mcg/kg an 10 ng/kg), were significantly better than that in the control (p(5). The result suggest that the gastric pentadecapeptide BPC-157 may have protectiv effect on reflux laryngitis in gastroesophageal reflux disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti