Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Effect of diets enriched with pumpkin-seed, olive and fish oil or lard on mice liver regeneration (CROSBI ID 575807)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Čanadi Jurešić, Gordana ; Broznić, Dalibor ; Marinić, Jelena ; Tota, Marin ; Čedomila, Milin Effect of diets enriched with pumpkin-seed, olive and fish oil or lard on mice liver regeneration // Book of Abstracts / Helga Medić (ur.). Hrvatsko društvo prehrambenih tehnologa, biotehnologa i nutricionista, 2011. str. 194-194

Podaci o odgovornosti

Čanadi Jurešić, Gordana ; Broznić, Dalibor ; Marinić, Jelena ; Tota, Marin ; Čedomila, Milin

engleski

Effect of diets enriched with pumpkin-seed, olive and fish oil or lard on mice liver regeneration

Introduction: The liver is remarkable organ, given its inherent capacity to fully restore itself after significant hepatic tissue loss either from partial hepatectomy (pHx) or acute liver injury. The best experimental model for the study of liver regeneration is a pHx, in which part of the liver is surgically removed. Fast liver growth, following pHx is well defined process, which involves the concerted action of extra and intracellular factors resulting in cell replication and its inhibition at the time when the entire liver mass is restored. Nutritional factors are one of the factors involved in this process. The aim of the study was to compare the effect of diets enriched with different oils or lard on liver regeneration, following 1/3 pHx in mice. Methodology: Male C57/Bl6 mice, aged 8-10 weeks, were fed by diets enriched either with pumpkin-seed, olive or fish oil or lard (5% addition to standard pellet, w/w) during the 3 weeks and afterwards subjected to 1/3 pHx. 2, 4, 24, 48 and 168 hours later mice were sacrificed and the remaining liver analysed. Total liver lipids were extracted and then separated into fractions by solid-phase extraction. Results and Discussion: Each of the experimental diets affected liver regeneration differently. In all diets, except in lard enriched diet, liver had regained much of its lost mass 48 hours after pHx, and regeneration finished after 196 hours. In all diets, except in fish oil enriched diets, regenerating liver accumulated extra fat (increment of neutral lipid fraction) in first few days after pHx, with the highest value at 24 hours after pHx. Fish oil enriched diet provoked the fastest liver regeneration (after 48 hours >90% of the original mass) and simultaneously, reflected itself in the lowest total liver lipid content. Conclusions: Enrichment of diets with fats, particularly fish oil, can improve liver regeneration.

liver regeneration; diets; fat

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

194-194.

2011.

nije evidentirano

objavljeno

978-953-99725-3-8

Podaci o matičnoj publikaciji

Book of Abstracts

Helga Medić

Hrvatsko društvo prehrambenih tehnologa, biotehnologa i nutricionista

Podaci o skupu

7th International Congress of Food Technologists, biotechnologists and nutritionists

poster

20.09.2011-23.09.2011

Opatija, Hrvatska

Povezanost rada

Temeljne medicinske znanosti, Biotehnologija