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Pregled bibliografske jedinice broj: 526884

Lewis acid promoted diastereoselective Mannich reaction of beta-lactam - tethered aldimines with 1-methoxy-1-trimethylsilyloxy-2, 2-dimethylethene


Habuš, Ivan; Vazdar, Katarina; Margetić, Davor
Lewis acid promoted diastereoselective Mannich reaction of beta-lactam - tethered aldimines with 1-methoxy-1-trimethylsilyloxy-2, 2-dimethylethene // ASMC, St. Petersburg ; International Symposium on Advances in Synthetic and Medicinal Chemistry / Nicolaou, K.C., Wood, Anthony (ur.).
St. Petersburg: LD Organisation sprl, 2011. str. 156-156 (poster, međunarodna recenzija, sažetak, ostalo)


Naslov
Lewis acid promoted diastereoselective Mannich reaction of beta-lactam - tethered aldimines with 1-methoxy-1-trimethylsilyloxy-2, 2-dimethylethene

Autori
Habuš, Ivan ; Vazdar, Katarina ; Margetić, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
ASMC, St. Petersburg ; International Symposium on Advances in Synthetic and Medicinal Chemistry / Nicolaou, K.C., Wood, Anthony - St. Petersburg : LD Organisation sprl, 2011, 156-156

Skup
International Symposium on Advances in Synthetic and Medicinal Chemistry

Mjesto i datum
St. Petersburg, Russia, 21-25.08.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Beta-lactam; Lewis acid; Mannich reaction

Sažetak
Lewis acid (ZnI2) - promoted Mannich reaction of azetidin-2-one - tethered aldimines 3a-r with silylenol ether 4 in toluene at -20 oC afforded a diastereomeric mixture of beta-amino acid esters 5a-r/6a-r. The effect of the ammount of zinc(II) iodide, temperature and a variety of groups on azetidin-2-one - tethered imines 3a-r (R1=phenyl, ferrocenyl ; R2=alkyl, aryl, ferrocenyl)on the chemical yield and the product stereoisomeric ratio was studied.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982915-2948 - Amino-beta-laktami - intermedijari u sintezi biološki interesantnih spojeva (Vlasta Tomašić, )
098-0982933-3218 - 'Host-guest' međudjelovanja u policikličkim sustavima (Davor Margetić, )

Ustanove
Institut "Ruđer Bošković", Zagreb