engleski

Lewis acid promoted diastereoselective Mannich reaction of beta-lactam - tethered aldimines with 1-methoxy-1-trimethylsilyloxy-2, 2-dimethylethene

Lewis acid (ZnI2) - promoted Mannich reaction of azetidin-2-one - tethered aldimines 3a-r with silylenol ether 4 in toluene at -20 oC afforded a diastereomeric mixture of beta-amino acid esters 5a-r/6a-r. The effect of the ammount of zinc(II) iodide, temperature and a variety of groups on azetidin-2-one - tethered imines 3a-r (R1=phenyl, ferrocenyl ; R2=alkyl, aryl, ferrocenyl)on the chemical yield and the product stereoisomeric ratio was studied.

beta-lactam; Lewis acid; Mannich reaction

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