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Tianeptine in the combined treatment of combat related posttraumatic stress disorder


Frančišković, Tanja; Šuković, Zoran; Janović, Sanja; Stevanović, Aleksandra; Nemčić Moro, Iva; Rončević Gržeta, Ika; Letica Crepulja, Marina
Tianeptine in the combined treatment of combat related posttraumatic stress disorder // Psychiatria Danubina, 23 (2011), 3; 257-263 (međunarodna recenzija, članak, znanstveni)


Naslov
Tianeptine in the combined treatment of combat related posttraumatic stress disorder
(TIianeptine in the combined treatment of combat related posttraumatic stress disorder)

Autori
Frančišković, Tanja ; Šuković, Zoran ; Janović, Sanja ; Stevanović, Aleksandra ; Nemčić Moro, Iva ; Rončević Gržeta, Ika ; Letica Crepulja, Marina

Izvornik
Psychiatria Danubina (0353-5053) 23 (2011), 3; 257-263

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tianeptine - fluoxetine - PTSD - treatment - war veterans

Sažetak
The aim of this study was to evaluate the efficacy of tianeptine, an antidepressant that acts by increasing serotonin reuptake, in the treatment of posttraumatic stress disorder and to compare the effects of tianeptine and fluoxetine, an antidepressant from the selective serotonin reuptake inhibitors class. 43 war veterans suffering from posttraumatic stress disorder were included in the study. During the 5.5 months of treatment 21 patients were receiving tianeptine and 22 were receiving fluoxetine. In addition, all patients took part in intensive trauma specific group psychotherapy. The effects of the two antidepressants on symptoms of PTSD, depression and anxiety after 5.5 months of treatment were assessed using the Harvard Trauma Questionnaire, Beck Depression Inventory, STAI and the List of Drug Use and Side Effects. There was no significant difference between the two treatment groups regarding their effect on symptoms and severity of depression. The level of anxiety was the same in the first measurement but the difference became significant in other three measurements in favor of tianeptine. The anxiolytics and other co-prescribed drugs remain the same in both groups, the use of analgesics significantly increase in fluoxetine group during the course of treatment. The study demonstrated that tianeptine is as effective as fluoxetine in the treatment of PTSD, with even stronger effect on anxiety and equal tolerance.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
130-1301422-1418 - Prilagodba pojedinca i zajednice u vrijeme društvene tranzicije (Dean Ajduković, )

Ustanove
Filozofski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE