Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 526630

An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157


Petrović, Igor; Dobrić, Ivan; Drviš, Petar; Shejbal, Dražen; Brčić, Luka; Boban Blagaić, Alenka; Batelja, Lovorka; Kokić, Neven; Tonkić, Ante; Miše, Stjepan et al.
An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157 // Journal of pharmacological sciences, 102 (2006), 3; 269-277 doi:10.1254/jphs.FP0060070 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 526630 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157

Autori
Petrović, Igor ; Dobrić, Ivan ; Drviš, Petar ; Shejbal, Dražen ; Brčić, Luka ; Boban Blagaić, Alenka ; Batelja, Lovorka ; Kokić, Neven ; Tonkić, Ante ; Miše, Stjepan ; Baotić, Tomislav ; Starešinić, Mario ; Radić, Božo ; Jakir, Ana ; Vukšić, Tihomir ; Anić, Tomislav ; Seiwerth, Swen ; Sikirić, Predrag

Izvornik
Journal of pharmacological sciences (1347-8613) 102 (2006), 3; 269-277

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BPC 157; esophagitis; sphincter (rat)

Sažetak
We report a simple novel rat model that combines prolonged esophagitis and parallel sphincters failure. The anti-ulcer gastric pentadecapeptide BPC 157, which was found to be stable in gastric juice, and is being evaluated in inflammatory bowel disease trials, is an antiesophagitis therapy that recovers failed sphincters. Twelve or twenty months after the initial challenge (tubes sutured into sphincters for one week and then spontaneously removed by peristalsis), rats exhibit prolonged esophagitis (confluent hemorrhagic and yellowish lesions, thinner epithelium and superficial corneal layer, with stratification derangement) ; constantly lowered pressure of both sphincters (assessed by using a water manometer connected to the drainage port of a Foley catheter implanted into the stomach either through esophageal or duodenal incision) ; and both lower esophageal and pyloric sphincter failure. Throughout the esophagitis experiment, BPC 157 was given at either 10 μg/kg, i.p., once a day (last application 24 h before assessment) or alternatively, it was given continuously in drinking water at 0.16 μg/ml (12 ml /rat). This treatment recovers i) esophagitis (macroscopically and microscopically, at either region or investigated time period) and ii) pressure in both sphincters (cmH2O). In addition, BPC 157 (10 μg/ kg) or saline (1 ml/ rat, 5 ml /kg) was specifically given directly into the stomach ; pressure assessment was performed at 5 min thereafter. The effect of BPC 157 is specific because in normal rats, it increases lower esophageal sphincter-pressure, but decreases pyloric sphincter-pressure. Ranitidine, given as the standard drug using the same protocol (50 mg/kg, i.p., once daily ; 0.83 mg/ ml in drinking water ; or 50 mg/ kg directly into the stomach) had no effect.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.jstage.jst.go.jp doi.org

Citiraj ovu publikaciju:

Petrović, Igor; Dobrić, Ivan; Drviš, Petar; Shejbal, Dražen; Brčić, Luka; Boban Blagaić, Alenka; Batelja, Lovorka; Kokić, Neven; Tonkić, Ante; Miše, Stjepan et al.
An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157 // Journal of pharmacological sciences, 102 (2006), 3; 269-277 doi:10.1254/jphs.FP0060070 (međunarodna recenzija, članak, znanstveni)
Petrović, I., Dobrić, I., Drviš, P., Shejbal, D., Brčić, L., Boban Blagaić, A., Batelja, L., Kokić, N., Tonkić, A. & Miše, S. (2006) An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157. Journal of pharmacological sciences, 102 (3), 269-277 doi:10.1254/jphs.FP0060070.
@article{article, author = {Petrovi\'{c}, Igor and Dobri\'{c}, Ivan and Drvi\v{s}, Petar and Shejbal, Dra\v{z}en and Br\v{c}i\'{c}, Luka and Boban Blagai\'{c}, Alenka and Batelja, Lovorka and Koki\'{c}, Neven and Tonki\'{c}, Ante and Mi\v{s}e, Stjepan and Baoti\'{c}, Tomislav and Stare\v{s}ini\'{c}, Mario and Radi\'{c}, Bo\v{z}o and Jakir, Ana and Vuk\v{s}i\'{c}, Tihomir and Ani\'{c}, Tomislav and Seiwerth, Swen and Sikiri\'{c}, Predrag}, year = {2006}, pages = {269-277}, DOI = {10.1254/jphs.FP0060070}, keywords = {BPC 157, esophagitis, sphincter (rat)}, journal = {Journal of pharmacological sciences}, doi = {10.1254/jphs.FP0060070}, volume = {102}, number = {3}, issn = {1347-8613}, title = {An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157}, keyword = {BPC 157, esophagitis, sphincter (rat)} }
@article{article, author = {Petrovi\'{c}, Igor and Dobri\'{c}, Ivan and Drvi\v{s}, Petar and Shejbal, Dra\v{z}en and Br\v{c}i\'{c}, Luka and Boban Blagai\'{c}, Alenka and Batelja, Lovorka and Koki\'{c}, Neven and Tonki\'{c}, Ante and Mi\v{s}e, Stjepan and Baoti\'{c}, Tomislav and Stare\v{s}ini\'{c}, Mario and Radi\'{c}, Bo\v{z}o and Jakir, Ana and Vuk\v{s}i\'{c}, Tihomir and Ani\'{c}, Tomislav and Seiwerth, Swen and Sikiri\'{c}, Predrag}, year = {2006}, pages = {269-277}, DOI = {10.1254/jphs.FP0060070}, keywords = {BPC 157, esophagitis, sphincter (rat)}, journal = {Journal of pharmacological sciences}, doi = {10.1254/jphs.FP0060070}, volume = {102}, number = {3}, issn = {1347-8613}, title = {An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157}, keyword = {BPC 157, esophagitis, sphincter (rat)} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font