The what, where, how and why of gene ontology - a primer for bioinformaticians (CROSBI ID 174103)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
du Plessis, Louis ; Škunca, Nives ; Dessimoz, Christopher
engleski
The what, where, how and why of gene ontology - a primer for bioinformaticians
With high-throughput technologies providing vast amounts of data, it has become more important to provide systematic, quality annotations. The Gene Ontology (GO) project is the largest resource for cataloguing gene function. Nonetheless, its use is not yet ubiquitous and is still fraught with pitfalls. In this review, we provide a short primer to the GO for bioinformaticians. We summarize important aspects of the structure of the ontology, describe sources and types of functional annotations, survey measures of GO annotation similarity, review typical uses of GO and discuss other important considerations pertaining to the use of GO in bioinformatics applications.
gene ontology; gene annotation; semantic similarity; gene function; function prediction
Special Issue: Collaborative Bioinformatics and RNA Analysis
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Podaci o izdanju
Povezanost rada
Biotehnologija, Biologija