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Improved antioxidant and anti-inflamatory potential in mice consuming sour cherry juice (Prunus Cerasus cv. Maraska)


Šarić, Ana; Sobočanec, Sandra; Balog, Tihomir; Kušić, Borka; Šverko, Višnja; Dragović-Uzelac, Verica; Levaj, Branka; Čosić, Zrinka; Mačak Šafranko, Željka; Marotti, Tatjana
Improved antioxidant and anti-inflamatory potential in mice consuming sour cherry juice (Prunus Cerasus cv. Maraska) // Plant foods for human nutrition, 64 (2009), 4; 231-237 doi:10.1007/s11130-009-0135-y (međunarodna recenzija, članak, znanstveni)


Naslov
Improved antioxidant and anti-inflamatory potential in mice consuming sour cherry juice (Prunus Cerasus cv. Maraska)

Autori
Šarić, Ana ; Sobočanec, Sandra ; Balog, Tihomir ; Kušić, Borka ; Šverko, Višnja ; Dragović-Uzelac, Verica ; Levaj, Branka ; Čosić, Zrinka ; Mačak Šafranko, Željka ; Marotti, Tatjana

Izvornik
Plant foods for human nutrition (0921-9668) 64 (2009), 4; 231-237

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cherry juice; antioxidant; lipid peroxidation; anti-inflamatory; cyanidin 3-glucoside; COX 2 activity

Sažetak
The present investigation tested the in vivo antioxidant efficacy (superoxide dismutase, SOD ; catalase, CAT ; glutathione peroxidase ; Gpx), lipid peroxidation (LPO) and anti-inflammatory properties (cyclooxygenase-2 ; COX-2) of sour cherry juices obtained from an autochthonous cultivar (Prunus cerasus cv. Maraska) that is grown in coastal parts of Croatia. Antioxidant potential was tested in mouse tissue (blood, liver, and brain), LPO (liver, brain) and anti-inflammatory properties in glycogen elicited macrophages. Additionally, the concentration of cyanidin-3-glucoside, cyanidin-3-rutinoside, pelargonidin-3-glucoside, pelargonidin-3-rutinoside and total anthocyanins present in Prunus cerasus cv. Maraska cherry juice was determined. Mice were randomly divided into a control group (fed with commercial food pellets) and 2 experimental groups (fed with commercial food pellets with 10% or 50% of cherry juice added). Among the anthocyanins, the cyanidin-3-glucoside was present in the highest concentration. These results show antioxidant action of cherry juice through increased SOD (liver, blood) and Gpx (liver) activity and decreased LPO concentration. The study highlights cherry juice as a potent COX-2 inhibitor and antioxidant in the liver and blood of mice, but not in the brain. Thus, according to our study, Prunus cerasus cv. Maraska cherry juice might potentially be used as an antioxidant and anti-inflammatory product with beneficial health– promoting properties.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
058-0000000-3488 - Biološki aktivni spojevi u nekim vrstama samoniklog i kultiviranog bilja (Verica Dragović-Uzelac, )
058-0580696-2728 - Promjene visokovrijednih sastojaka tijekom prerade odabranih vrsta voća (Branka Levaj, )
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Tihomir Balog, )

Ustanove
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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