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Pregled bibliografske jedinice broj: 523790

Cytochrome P450 gender-related differences in response to hyperoxia in young CBA mice


Mačak-Šafranko, Željka; Sobočanec, Sandra; Šarić, Ana; Balog, Tihomir; Šverko, Višnja; Kušić, Borka; Marotti, Tatjana
Cytochrome P450 gender-related differences in response to hyperoxia in young CBA mice // Experimental and toxicologic pathology, 63 (2011), 4; 345-350 doi:10.1016/j.etp.2010.02.009 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 523790 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cytochrome P450 gender-related differences in response to hyperoxia in young CBA mice

Autori
Mačak-Šafranko, Željka ; Sobočanec, Sandra ; Šarić, Ana ; Balog, Tihomir ; Šverko, Višnja ; Kušić, Borka ; Marotti, Tatjana

Izvornik
Experimental and toxicologic pathology (0940-2993) 63 (2011), 4; 345-350

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytochrome P450; hyperoxia; CBA mice

Sažetak
Cytochrome P450 monooxygenases (CYPs) represent large class of heme-containing enzymes that catalyze the metabolism of various endogenous and exogenous substrates. Although they are found in many tissues, the function of the particular subset of their isoforms does not appear to be the same. Many CYP genes exhibit sexually dimorphic expression, while others are sex-independent. Moreover, as a source of reactive oxygen species (ROS), P450 system is believed to play the important role in various pathological conditions and diseases. The aim of this study was to observe the effect of hyperoxia on oxidant/antioxidant status in the liver of young male and female mice and to determine whether the observed effects are associated with the expression of Heme oxygenase-1 (HO-1) and CYP genes associated with stress (Cyp1a1, Cyp1a2, Cyp2a5, and Cyp2e1) or stress and gender-related responses (Cyp2b9). In this study, we demonstrated gender-related effect of hyperoxia on oxidant/antioxidant status and on expression of certain P450 enzymes. Our results suggest that females are less susceptible to hyperoxia induced oxidative stress by two major mechanisms: upregulated expression of HO-1 genes and different expression of certain P450 enzymes. Therefore, our study could provide additional data of gender-dependent responses in susceptibility to oxidative stress, chemical toxicity and drug efficiency in treatment of diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Balog, Tihomir, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Mačak-Šafranko, Željka; Sobočanec, Sandra; Šarić, Ana; Balog, Tihomir; Šverko, Višnja; Kušić, Borka; Marotti, Tatjana
Cytochrome P450 gender-related differences in response to hyperoxia in young CBA mice // Experimental and toxicologic pathology, 63 (2011), 4; 345-350 doi:10.1016/j.etp.2010.02.009 (međunarodna recenzija, članak, znanstveni)
Mačak-Šafranko, Ž., Sobočanec, S., Šarić, A., Balog, T., Šverko, V., Kušić, B. & Marotti, T. (2011) Cytochrome P450 gender-related differences in response to hyperoxia in young CBA mice. Experimental and toxicologic pathology, 63 (4), 345-350 doi:10.1016/j.etp.2010.02.009.
@article{article, author = {Ma\v{c}ak-\v{S}afranko, \v{Z}eljka and Sobo\v{c}anec, Sandra and \v{S}ari\'{c}, Ana and Balog, Tihomir and \v{S}verko, Vi\v{s}nja and Ku\v{s}i\'{c}, Borka and Marotti, Tatjana}, year = {2011}, pages = {345-350}, DOI = {10.1016/j.etp.2010.02.009}, keywords = {cytochrome P450, hyperoxia, CBA mice}, journal = {Experimental and toxicologic pathology}, doi = {10.1016/j.etp.2010.02.009}, volume = {63}, number = {4}, issn = {0940-2993}, title = {Cytochrome P450 gender-related differences in response to hyperoxia in young CBA mice}, keyword = {cytochrome P450, hyperoxia, CBA mice} }
@article{article, author = {Ma\v{c}ak-\v{S}afranko, \v{Z}eljka and Sobo\v{c}anec, Sandra and \v{S}ari\'{c}, Ana and Balog, Tihomir and \v{S}verko, Vi\v{s}nja and Ku\v{s}i\'{c}, Borka and Marotti, Tatjana}, year = {2011}, pages = {345-350}, DOI = {10.1016/j.etp.2010.02.009}, keywords = {cytochrome P450, hyperoxia, CBA mice}, journal = {Experimental and toxicologic pathology}, doi = {10.1016/j.etp.2010.02.009}, volume = {63}, number = {4}, issn = {0940-2993}, title = {Cytochrome P450 gender-related differences in response to hyperoxia in young CBA mice}, keyword = {cytochrome P450, hyperoxia, CBA mice} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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