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Novel amino substituted derivatives of benzimidazo[1, 2-a]quinolines and benzo[b]thieno[2, 3-c]quinolones


Karminski-Zamola, Grace; Aleksić, Maja; Perin, Nataša; Hranjec, Marijana; Uzelac, Lidija; Kralj, Marijeta; Piantanida, Ivo
Novel amino substituted derivatives of benzimidazo[1, 2-a]quinolines and benzo[b]thieno[2, 3-c]quinolones // International Symposium on Advances in Synthetic and Medicinal Chemistry : Abstracts / Nicolaou, K.C. (ur.).
St. Petersburg, 2011. str. 184-184 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Novel amino substituted derivatives of benzimidazo[1, 2-a]quinolines and benzo[b]thieno[2, 3-c]quinolones

Autori
Karminski-Zamola, Grace ; Aleksić, Maja ; Perin, Nataša ; Hranjec, Marijana ; Uzelac, Lidija ; Kralj, Marijeta ; Piantanida, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Symposium on Advances in Synthetic and Medicinal Chemistry : Abstracts / Nicolaou, K.C. - St. Petersburg, 2011, 184-184

Skup
International Symposium on Advances in Synthetic and Medicinal Chemistry

Mjesto i datum
St. Petersburg, Rusija, 21.-25.08.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Benzimidazo[1; 2-a]quinolines; benzo[b]thieno[2; 3-c]quinolones; amino-substituted derivatives; antitumor activity; interaction with ct-DNA

Sažetak
One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with antitumor activity. Previously prepared derivatives of benzimidazo[1, 2-a]quinolines and benzo[b]thieno[2, 3-c]quinolones showed very good antitumor activity in vitro on a number of human tumor cell lines. Some of these compounds efficiently bind to double-stranded polynucleotides by intercalation.1-3 This work presents, as a part of our continuing research in the field of medicinal chemistry, the synthesis of novel amino-substituted derivatives of benzimidazo[1, 2-a]quinolines and benzo[b]thieno[2, 3-c]quinolones, as a potential biologically active agents. For the preparation of targeted compounds, clasicall reactions of organic chemistry and photochemistry were used. All compounds were characterized by 1H, 13C NMR, IR, UV/Vis and fluorimetric spectroscopy. Antitumor activity in vitro was tested on several human tumor cell lines. Interaction with ct-DNA of derivatives of benzimidazo[1, 2-a]quinolines was studied by using 4 different methods including thermal denaturation experiment, spectroscopic UV/Vis, fluorimetric and CD titrations with ct-DNA. [1] Hranjec, M., Kralj, M., Piantanida, I., Sedić, M., Šuman, L., Pavelić, K., Karminski-Zamola, G., J. Med. Chem. 50 (2007) 5696. [2] Hranjec, M., Pavlović, G., Marjanović, M., Kralj, M., Karminski-Zamola, G., Eur. J. Med. Chem. 45 (2010) 2405. [3] Jarak, I. ; Kralj, M. ; Šuman, L. ; Pavlović, G. ; Dogan, J. ; Piantanida, I. ; Žinić, M. ; Pavelić, K. ; Karminski-Zamola, G. J. Med. Chem. 2005, 48, 2346-2360.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni ("pametni") lijekovi (Marijana Hranjec, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb