engleski

Synthesis and Immunostimulating Properties of Novel Adamant-1-yl Tripeptides

The aim of this work was to prepare L- and D- (adamant-1-yl)-Gly-L-Ala-D-isoGln peptides in order to study their adjuvant (immunostimulating) activity. Adjuvant activity of adamant-1-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D- MurNAc-L-Ala-D-isoGln-mesoDAP(εNH2)-D-Ala-D-Ala) and structurally related adamant-2-yl tripeptides.

adamant-1-yl tripeptides ; immunostimulating activity ; adamant-2-yl tripeptides ; peptidoglycan monomer

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