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Synthesis and biological evaluation of a novel series of 1, 3-dicoumarinyl-5-aryl-2-pyrazolines


Čačić, Milan; Molnar, Maja; Strelec, Ivica
Synthesis and biological evaluation of a novel series of 1, 3-dicoumarinyl-5-aryl-2-pyrazolines // Heterocycles, 83 (2011), 7; 1553-1566 doi:10.3987/COM-11-12196 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis and biological evaluation of a novel series of 1, 3-dicoumarinyl-5-aryl-2-pyrazolines

Autori
Čačić, Milan ; Molnar, Maja ; Strelec, Ivica

Izvornik
Heterocycles (0385-5414) 83 (2011), 7; 1553-1566

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Coumarin; pyrazoline; antioxidant

Sažetak
In the present paper novel 1, 3, 5-trisubstituted 2-pyrazolines (4a-q) were synthesized via condensation of different substituted 3-cinnamoyl-2-oxo-2H-chromenes (2a-q) with 2-(4-methyl-2-oxo-2H-chromen-7- yloxy)acetohydrazide (3). Chalcones were prepared via Claisen-Schmidt condensation by refluxing 3-acetyl-2-oxo-2H-chromen (1) with corresponding aldehydes in ethanol, in the presence of piperidine. All of these compounds were characterized by means of their IR, 1H NMR and LC/MS/MS spectroscopic data and elemental microanalysis. Chalcones and pyrazolines were screened for their antioxidant and iron chelating activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija, Prehrambena tehnologija



POVEZANOST RADA


Projekt / tema
113-1130473-0334 - Sinergističke smjese u antifungalnoj i antimikotoksigenoj zaštiti hrane (Tomislav Klapec, )

Ustanove
Prehrambeno-tehnološki fakultet, Osijek

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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