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Serum elastase on the third day is a valuable predictor of systemic complications in patients with acute pancreatitis


Fišić, Elizabeta; Bilić-Zulle, Lidija; Poropat, Goran; Štimac, Davor
Serum elastase on the third day is a valuable predictor of systemic complications in patients with acute pancreatitis // Pancreatology
Magdeburg, Njemačka, 2011. str. 176-176 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Serum elastase on the third day is a valuable predictor of systemic complications in patients with acute pancreatitis

Autori
Fišić, Elizabeta ; Bilić-Zulle, Lidija ; Poropat, Goran ; Štimac, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pancreatology / - , 2011, 176-176

Skup
43rd European Pancreatic Club

Mjesto i datum
Magdeburg, Njemačka, 22-25.06.2011.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Elastase; acute pancreatitis; severity

Sažetak
Introduction: Serum pancreatic elastase (E1) concentration rises significantly in acute pancreatitis (AP). Many studies confirmed that E1 has no value in prediction of complications on the first day. However, only few studies have shown its significance in prediction of severe disease cases on the third day. Objectives: To evaluate the use and accuracy of E1 in the prediction of severity of AP. Patients and Methods: In 156 admitted to our hospital with a confirmed diagnosis of AP, we measured E1 on the first and third day upon admission. Measurements were performed by immunoenzymometric principles, and refferent values were as determined by the manufacturer (<3.5 ng/ml). Statistical analysis was performed using Mann-Whitney test and ROC analysis. Results: We confirmed a statistically significant decrease of E1 between the first (median = 5.9, 95% CI 4.3–7.5), and third (median = 1.8, 95% CI 1.6–2.2) day (p < 0.001). We did not find a significant difference in E1 values on the first day between patients with and without complications (p = 0.249). However, a significant difference occurred on the third day (1.7, 95% CI 1.4–1.9 vs. 2.5, 95% CI 2.1–5.1 ; p < 0.001). ROC analysis was performed for the latter and confirmed a significant decrease of E1 in patients with complications on the third day (AUC 0.70 ; 95% CI 0.62–0.77 ; cut-off = 1.5 ; sensitivity 93% ; specificity 43%, PPV 27% ; NPV 96% ; p < 0.001). Conclusions: Our results showed that the decrease of E1 concentrations on the third day are significantly correlated with severe cases of AP and a higher rate of systemic complications.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-0211 - Učinci enteralne prehrane u teškom akutnom pankreatitisu (Davor Štimac, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE