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Pregled bibliografske jedinice broj: 519091

Emergence of karyotypically unrelated clone during complete remission of acute monocytic leukemia


Petkovic, Iskra; Konja, Josip; Lasan, Ruška; Petkovic, Giorgie; Aničić, Mirna
Emergence of karyotypically unrelated clone during complete remission of acute monocytic leukemia // European Journal of Human Genetics / Karin, Knob (ur.).
London: Nature Publishing Group, 2011. str. 242-242 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 519091 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Emergence of karyotypically unrelated clone during complete remission of acute monocytic leukemia

Autori
Petkovic, Iskra ; Konja, Josip ; Lasan, Ruška ; Petkovic, Giorgie ; Aničić, Mirna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Human Genetics / Karin, Knob - London : Nature Publishing Group, 2011, 242-242

Skup
European Human Genetic Conference 2011

Mjesto i datum
Amsterdam, 28-31.05.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Clonal aberrations; children; AML

Sažetak
AML is a heterogeneous group of disease. Besides morphological and cytogenetic heterogeneity, of interest are different types of remissions. One form of remission is characterized by repopulation of the marrow by normal cells, and the other by clonal cell proliferation. The data on clonal remission are limited, and some 40 cases have been reported so far. The frequency of clonal remission is variable and range from 1% to 12% of acute leukemia. Nature, mechanisms of origin and clinical significance of clonal cell proliferation at remission are not elucidated yet. We present the results of clinical and cytogenetic investigation in a girl with AML and unrelated clonal chromosome aberration during remission and literature review of published data on clonal remission in patient with acute leukemia. Our patient is 3½-old-girl referred to the hospital with hepatospenomegaly, hematomas and polymicroadenia. Cytomorphologic analysis revealed AML-M5A. Chromosome study at diagnosis showed abnormal clone with 48, XX, +21, +mar and at remission following induction therapy a normal karyotype was observed. Eleven months after diagnosis, while the patient was in first complete remission an unrelated abnormal clone with t(1 ; 18) was observed. This report highlights the importance of cytogenetic study in patients follow up and detection of unrelated clonal rearrangement during remission of acute leukemia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
072-1083107-0361 - Telomere i kromosomske aberacije u patologiji dječje dobi (Petković, Iskra, MZOS - )
108-0000000-0049 - Zloćudne bolesti u djece (Konja, Josip, MZOS - )

Ustanove
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Iskra Petković (autor)

Avatar Url Giorgie Petković (autor)

Avatar Url Josip Konja (autor)

Citiraj ovu publikaciju

Petkovic, Iskra; Konja, Josip; Lasan, Ruška; Petkovic, Giorgie; Aničić, Mirna
Emergence of karyotypically unrelated clone during complete remission of acute monocytic leukemia // European Journal of Human Genetics / Karin, Knob (ur.).
London: Nature Publishing Group, 2011. str. 242-242 (poster, međunarodna recenzija, sažetak, znanstveni)
Petkovic, I., Konja, J., Lasan, R., Petkovic, G. & Aničić, M. (2011) Emergence of karyotypically unrelated clone during complete remission of acute monocytic leukemia. U: Karin, K. (ur.)European Journal of Human Genetics.
@article{article, editor = {Karin, K.}, year = {2011}, pages = {242-242}, keywords = {Clonal aberrations, children, AML}, title = {Emergence of karyotypically unrelated clone during complete remission of acute monocytic leukemia}, keyword = {Clonal aberrations, children, AML}, publisher = {Nature Publishing Group}, publisherplace = {Amsterdam} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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