Over-represented localized sequence motifs in ribosomal protein gene promoters of basal metazoans (CROSBI ID 172690)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Perina, Dragutin ; Korolija, Marina ; Roller, Maša ; Harcet, Matija ; Jeličić, Branka ; Mikoč, Andreja ; Ćetković, Helena
engleski
Over-represented localized sequence motifs in ribosomal protein gene promoters of basal metazoans
Equimolecular presence of ribosomal proteins (RPs) in the cell is needed for ribosome assembly and is achieved by synchronized expression of ribosomal protein genes (RPGs) with promoters of similar strengths. Over-represented motifs of RPG promoter regions are identified as targets for specific transcription factors. Unlike RPs, those motifs are not conserved between mammals, drosophila and yeast. We analyzed RPGs proximal promoter regions of three basal metazoans with sequenced genomes: sponge, cnidarian and placozoan and found common features, such as 5’-terminal oligopyrimidine tracts and TATA-boxes. Furthermore, we identified over-represented motifs, some of which displayed the highest similarity to motifs abundant in human RPG promoters and not present in Drosophila or yeast. Our results indicate that human over-represented motifs, as well as corresponding domains of transcription factors were established very early in metazoan evolution. The fast evolving nature of RPGs regulatory network leads to formation of other, lineage specific, over-represented motifs.
ribosomal proteins ; ribosomal protein gene promoters ; Porifera ; Cnidaria ; Placozoa.
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
98 (1)
2011.
56-63
objavljeno
0888-7543
1089-8646
10.1016/j.ygeno.2011.03.009