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Difference in expression of collagen type I and matrix metalloproteinase-1 in uterosacral ligaments of women with and without pelvic organ prolapse


Vulić, Marko; Strinić, Tomislav; Tomić, Snježana; Ćapkun, Vesna; Jakus Alujević, Ivana; Stipić, Ivica
Difference in expression of collagen type I and matrix metalloproteinase-1 in uterosacral ligaments of women with and without pelvic organ prolapse // European journal of obstetrics, gynecology, and reproductive biology, 155 (2011), 2; 225-228 doi:10.1016/j.ejogrb.2010.12.019 (međunarodna recenzija, članak, znanstveni)


Naslov
Difference in expression of collagen type I and matrix metalloproteinase-1 in uterosacral ligaments of women with and without pelvic organ prolapse

Autori
Vulić, Marko ; Strinić, Tomislav ; Tomić, Snježana ; Ćapkun, Vesna ; Jakus Alujević, Ivana ; Stipić, Ivica

Izvornik
European journal of obstetrics, gynecology, and reproductive biology (0301-2115) 155 (2011), 2; 225-228

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Collagen I; MMP-1; pelvic organ prolapse

Sažetak
Aim was to compare the expression of collagen type I and matrix metalloproteinase-1 (MMP-1) in uterosacral ligament biopsies from women with and without pelvic organ prolapse (POP). Uterosacral ligament biopsies were obtained from women with POP (n=46) and control subjects (n=49). Immunohistochemistry for collagen type I and MMP-1 was performed on formalin-fixed and paraffin-embedded sections. The two groups were matched for age, body mass index, parity and postmenopausal status. Statistical Package for the Social Sciences Version 13.0 was used for statistical analysis. The expression of collagen type I (p=0.034) and MMP-1 (p=0.038) differed between women with POP and control subjects. There was increased expression of MMP-1 and decreased expression of collagen type 1 in uterosacral ligaments of women with POP compared with control subjects. This difference indicates a possible relationship between POP and the immunohistochemical expression of collagen type I and MMP-1 in uterosacral ligaments.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-0000000-0484 - Dvostruki model ovarijalne kancerogeneze - molekularna i morfološka studija (Snježana Tomić, )
216-0000000-0535 - Metabolizam kolagena u sindromu spuštenih genitalnih organa (Tomislav Strinić, )

Ustanove
Medicinski fakultet, Split

Citiraj ovu publikaciju

Vulić, Marko; Strinić, Tomislav; Tomić, Snježana; Ćapkun, Vesna; Jakus Alujević, Ivana; Stipić, Ivica
Difference in expression of collagen type I and matrix metalloproteinase-1 in uterosacral ligaments of women with and without pelvic organ prolapse // European journal of obstetrics, gynecology, and reproductive biology, 155 (2011), 2; 225-228 doi:10.1016/j.ejogrb.2010.12.019 (međunarodna recenzija, članak, znanstveni)
Vulić, M., Strinić, T., Tomić, S., Ćapkun, V., Jakus Alujević, I. & Stipić, I. (2011) Difference in expression of collagen type I and matrix metalloproteinase-1 in uterosacral ligaments of women with and without pelvic organ prolapse. European journal of obstetrics, gynecology, and reproductive biology, 155 (2), 225-228 doi:10.1016/j.ejogrb.2010.12.019.
@article{article, year = {2011}, pages = {225-228}, DOI = {10.1016/j.ejogrb.2010.12.019}, keywords = {collagen I, MMP-1, pelvic organ prolapse}, journal = {European journal of obstetrics, gynecology, and reproductive biology}, doi = {10.1016/j.ejogrb.2010.12.019}, volume = {155}, number = {2}, issn = {0301-2115}, title = {Difference in expression of collagen type I and matrix metalloproteinase-1 in uterosacral ligaments of women with and without pelvic organ prolapse}, keyword = {collagen I, MMP-1, pelvic organ prolapse} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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