hrvatski

HFE MUTACIJE I C1/C2 POLIMORFIZAM GENA ZA TRANSFERIN U HRVATSKIH BOLESNIKA SA SHIZOFRENIJOM I SHIZOAFEKTIVNIM POREMEĆAJEM

OBJECTIVE: To investigate the possible influence of hemochromatosis gene mutations (HFE-C282Y and H63D) and transferrin gene C2 variant (TF-C2) on susceptibility to schizophrenia and schizoaffective disorder and/or age at first hospital admission. METHODS: Genotyping was performed in 176 Croatian patients and 171 non-psychiatric Croatian controls using PCR-RFLP analyses. RESULTS: Allele and genotype distributions were not significantly different between two groups. After the age at first admission was analyzed as a continuous variable using the non-parametric Mann-Whitney U-test and Kruskal-Wallis test with negative results, the variable was dichotomized using 40 years as the cutoff. H63D-TFC2 bi-carriers were over-represented among patients in the late disease-onset group [≥ 40 years ; 7.5% vs. 25%, odds ratio (OR) = 0.243, 95% confidence interval (CI) = 0.068-0.871 ; P=0.030]. Multiple regression analysis showed no effect of combined H63D-TFC2 genotype to distribution of age at disease-onset in our sample. CONCLUSION: Investigated HFE mutations and TF-C2 variant are not high-risk genetic variants for schizophrenia/schizoaffective disorder in our population. Also, our data do not support their impact on age at onset of the first psychotic symptoms.

shizofrenija; shizoafektivni poremećaj; mutacije u genu za hemokromatozu; C1/C2 polimorfizam gena za transferin; dob prve hospitalizacije

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