engleski

Biological, Clinical And Demographic Parameters At The Time Of Diagnosis Are Important For Prognosis NSCLC

RATIONALE: Early diagnosis of lung cancer is mandatory for better survival. Early detection of recurrence is important for successuful therapy monitoring. Responsibility lies in the patient but also in the insufficiency of our diagnostic. Parameters at the time of diagnosis help to isolate patients with higher risk and to replace standard therapy protocols with more efficiency ones. METHODS: 2620 NSCLC patients were follow-up 6 years from the time of diagnosis and surgery. Demographic, clinical and biological parameters were collected: sex, age, risk factor, tumor type, tumor necrosis, T3 with invasion, tumor size, stage, TNM classification, neoadjuvant therapy, type of lung surgery, clinical recurrence, reoperation of the lung, cerebral surgery, a month of death, longitudinal measurement of CYFRA 21-1 and CYFRA 21-1 relapse. Data were analyzed by univariate log-rank and multivariate Cox analysis. RESULTS: From SQC patients survived 611 (45.2%) without relapse and 211 (28.5%) with relapse. In AD patients alive were 554 (54.19%) of which 427 (42%) without relapse and 127 (21.69%) with relapse. From LCC 78 (30%) patients were without recurrence, and with relapse and additional therapy 40 (22%). The most important prognostic variables in NSCLC are CYFRA 21-1 at the time of diagnosis (HR 1.86, p = 0.0000), histopathologic type of tumor (HR 1.61, p = 0.0000), TNM classification (HR 1:30, p = 0.0000), N of the TNM classification (HR 1:28, p = 0.0036), T3, with invasion (HR 1:23, p = 0.0230) and the difference between the recurrence sugeriranog with CYFRA 21-1 and clinical recurrence (HR 1:23, p = 0.0000). CONCLUSIONS: The knowledge of biological, clinical and demographic parameters is crucial to better survival of NSCLC with current treatments. Especially this applies to parameters that were significant in multivariate analysis. The presented are the result of an individual approach to application and interpretation of biomarkers and all parameters that notice affected the radically operated NSCLC in 12 years of teamwork different specialists.

Lung cancer; diagnosis

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