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Pregled bibliografske jedinice broj: 517185

VEGH and HIF-1α expression in nephroblastoma correlates with anaplasia


Pajić, Anto; Džombeta, Tihana; Cigrovski, Nevenka; Radulović, Petra; Čizmić, Ante; Stepan, Jasminka; Krušlin, Božo
VEGH and HIF-1α expression in nephroblastoma correlates with anaplasia // Paediatria Croatica, 54 (2010), 3; 125-128 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 517185 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
VEGH and HIF-1α expression in nephroblastoma correlates with anaplasia

Autori
Pajić, Anto ; Džombeta, Tihana ; Cigrovski, Nevenka ; Radulović, Petra ; Čizmić, Ante ; Stepan, Jasminka ; Krušlin, Božo

Izvornik
Paediatria Croatica (1330-1403) 54 (2010), 3; 125-128

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
VEGF-A protein, human ; hypoxia-inducible factor 1, alpha subunit ; Wilms tumour ; anaplasia

Sažetak
HIF-1α (hypoxia inducible factor 1α) is a transcription factor that has a role in maintaining oxygen homeostasis. Increased expression of HIF-1α leads to a rise in amount of VEGF (vascular endothelial growth factor), thus inducing neovascularization. The aim of this study was to determine the expression of VEGF and HIF-1α in nephroblastoma and to compare it with the clinical and pathohistological characteristics of this tumour (dominant histological component, presence of anaplasia and necrosis, size of the tumour, age and sex of the patient). Expression of VEGF and HIF-1α was determined by immunohistochemistry of the tumour tissue. Monoclonal mouse anti-VEGF and polyclonal rabbit anti-HIF-1α antibodies were used. For immunoscoring of both markers the degree of positive staining was evaluated semiquantitatively. The χ²-test, which includes Spearman’s rank correlation and the ANOVA test were used for statistical analysis of data. Most of the tumours were positive for VEGF (38/40) and HIF-1α (37/40). Significant statistical correlation was found between HIF-1α and the presence of anaplasia (p=0.02986). A clear correlation between VEGF and tumour size was established (Spearman’s rank correlation: p=0.0027), showing strong positivity in larger tumours. Based on this study we can conclude that VEGF and HIF-1α are present in Wilms’ tumours, playing an important role in angiogenesis and tumour progression.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
MZOS-108-1081870-1884 - Razvojna neuropatologija genetskih malformacija moždane kore čovjeka (Krušlin, Božo, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinika za dječje bolesti

Poveznice na cjeloviti tekst rada:

www.paedcro.com

Citiraj ovu publikaciju:

Pajić, Anto; Džombeta, Tihana; Cigrovski, Nevenka; Radulović, Petra; Čizmić, Ante; Stepan, Jasminka; Krušlin, Božo
VEGH and HIF-1α expression in nephroblastoma correlates with anaplasia // Paediatria Croatica, 54 (2010), 3; 125-128 (međunarodna recenzija, članak, znanstveni)
Pajić, A., Džombeta, T., Cigrovski, N., Radulović, P., Čizmić, A., Stepan, J. & Krušlin, B. (2010) VEGH and HIF-1α expression in nephroblastoma correlates with anaplasia. Paediatria Croatica, 54 (3), 125-128.
@article{article, author = {Paji\'{c}, Anto and D\v{z}ombeta, Tihana and Cigrovski, Nevenka and Radulovi\'{c}, Petra and \v{C}izmi\'{c}, Ante and Stepan, Jasminka and Kru\v{s}lin, Bo\v{z}o}, year = {2010}, pages = {125-128}, keywords = {VEGF-A protein, human, hypoxia-inducible factor 1, alpha subunit, Wilms tumour, anaplasia}, journal = {Paediatria Croatica}, volume = {54}, number = {3}, issn = {1330-1403}, title = {VEGH and HIF-1α expression in nephroblastoma correlates with anaplasia}, keyword = {VEGF-A protein, human, hypoxia-inducible factor 1, alpha subunit, Wilms tumour, anaplasia} }
@article{article, author = {Paji\'{c}, Anto and D\v{z}ombeta, Tihana and Cigrovski, Nevenka and Radulovi\'{c}, Petra and \v{C}izmi\'{c}, Ante and Stepan, Jasminka and Kru\v{s}lin, Bo\v{z}o}, year = {2010}, pages = {125-128}, keywords = {VEGF-A protein, human, hypoxia-inducible factor 1, alpha subunit, Wilms tumour, anaplasia}, journal = {Paediatria Croatica}, volume = {54}, number = {3}, issn = {1330-1403}, title = {VEGH and HIF-1α expression in nephroblastoma correlates with anaplasia}, keyword = {VEGF-A protein, human, hypoxia-inducible factor 1, alpha subunit, Wilms tumour, anaplasia} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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