engleski

Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro - prevention of amyloid-induced glutathione depletion

Effective drugs are not available to protect against beta-amyloid peptide (A beta)-induced neurotoxicity. COrtical neurons from rat embryos were treated with the toxic fragment A beta 25-35 at 1 mu M in the presence or absence of flupirtine, a triaminopyridine, successfully applied clinically as nonopiate analgesic drug.

Alzheimers disease; amyloid; amyotrophic lateral sclerosis; oxidative stress; flupirtine; triaminopyridine

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