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Insomnia, platelet serotonin and platelet monoamine oxidase in chronic alcoholism (CROSBI ID 172310)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Nenadić Šviglin, Korona ; Nedić, Gordana ; Nikolac, Matea ; Mustapić, Maja ; Muck-Šeler, Dorotea ; Borovečki, Fran ; Pivac, Nela Insomnia, platelet serotonin and platelet monoamine oxidase in chronic alcoholism // Neuroscience letters, 500 (2011), 3; 172-176. doi: 10.1016/j.neulet.2011.06.026

Podaci o odgovornosti

Nenadić Šviglin, Korona ; Nedić, Gordana ; Nikolac, Matea ; Mustapić, Maja ; Muck-Šeler, Dorotea ; Borovečki, Fran ; Pivac, Nela

engleski

Insomnia, platelet serotonin and platelet monoamine oxidase in chronic alcoholism

Insomnia is a common sleep disorder frequently occurring in chronic alcoholic patients. Neurobiological basis of insomnia, as well as of alcoholism, is associated with disrupted functions of the main neurotransmitter systems, including the serotonin (5-hydroxytryptamine, 5-HT) system. Blood platelets are considered a limited peripheral model for the central 5-HT neurons, since both platelets and central 5-HT synaptosomes have similar dynamics of 5-HT. Platelet 5-HT concentration and platelet monoamine oxidase type B (MAO-B) are assumed to represent biomarkers for particular symptoms and behaviors in psychiatric disorders. The hypothesis of this study was that platelet 5-HT concentration and platelet MAO-B activity will be altered in chronic alcoholic patients with insomnia compared to comparable values in patients without insomnia. The study included 498 subjects: 395 male and 103 female medication-free patients with alcohol dependence and 502 healthy control subjects: 325 men and 177 women. The effects of early, middle and late insomnia (evaluated using the Hamilton Depression Rating Scale), as well as sex, age and smoking on platelet 5-HT concentration and platelet MAO-B activity were evaluated using one-way ANOVA and multiple regression analysis by the stepwise method. Platelet 5-HT concentration, but not platelet MAO-B activity, was significantly reduced in alcoholic patients with insomnia compared to patients without insomnia. Multiple regression analysis revealed that platelet 5-HT concentration was affected by middle insomnia, smoking and sex, while platelet MAO activity was affected only by sex and age. The present and previous data suggest that platelet 5-HT concentration might be used, after controlling for sex and smoking, as a biomarker for insomnia in alcoholism, PTSD and in rotating shift workers.

alcoholism ; insomnia ; platelet serotonin ; platelet monoamine oxidase ; smoking

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Podaci o izdanju

500 (3)

2011.

172-176

objavljeno

0304-3940

1872-7972

10.1016/j.neulet.2011.06.026

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

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