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Sinteza novih pirimidinskih derivata L-askorbinske kiseline radi ispitivanja citostatskih djelovanja


Wittine, Karlo; Stipković-Babić, Maja; Košutić, Marija; Mintas, Mladen
Sinteza novih pirimidinskih derivata L-askorbinske kiseline radi ispitivanja citostatskih djelovanja // XXII. Hrvatski skup kemičara i kemijskih inženjera/XXII. Croatian meeting of chemists and chemical engineers / Vesna Tomašić, Karolina Maduna Valkaj (ur.).
Zagreb: HDKI/Kemija u industriji, 2011. str. 217-217 (poster, domaća recenzija, sažetak, znanstveni)


Naslov
Sinteza novih pirimidinskih derivata L-askorbinske kiseline radi ispitivanja citostatskih djelovanja
(Synthesis of the novel pyrimidine derivatives of L-ascorbic acid for their cytostatic activity evaluations)

Autori
Wittine, Karlo ; Stipković-Babić, Maja ; Košutić, Marija ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXII. Hrvatski skup kemičara i kemijskih inženjera/XXII. Croatian meeting of chemists and chemical engineers / Vesna Tomašić, Karolina Maduna Valkaj - Zagreb : HDKI/Kemija u industriji, 2011, 217-217

ISBN
978-953-6894-42-0

Skup
XXII. Hrvatski skup kemičara i kemijskih inženjera/XXII. Croatian meeting of chemists and chemical engineers

Mjesto i datum
Zagreb, Hrvatska, 13.-16. veljače 2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Pirimidinski derivati; L-askorbinska kiselina
(Pyrimidine derivatives; L-ascorbic acid)

Sažetak
Nucleoside analogues represent a valuable source that contributes significantly to the arsenal of chemotherapeutic agents against viruses and cancer. In recent years a number of five-membered cytosine nucleoside analogues, such as 1-(2-deoxy-2-methylene--D-erythro-pentofuranosyl) cytosine (DMDC) [1], 2'-deoxy-2', 2'-difluorocytidine (gemcitabine) [2], and 1-(2-C-cyano-2-deoxy--D-arabino-pentofuranosyl) cytosine (CNDAC) [3], have been developed as potent antitumor agents, which are effective not only on leukemias and lymphomas, but also on a wide variety of solid tumor in vitro and in vivo. Cameron and Pauling believed that L-ascorbic acid combats cancer by promoting collagen synthesis and thus preventing tumors from invading other tissues. However, researchers now believe that L-ascorbic acid combats cancer by neutralizing free radicals before they can damage DNA and initiate tumor growth and/or may act as a pro-oxidant helping body's own free radicals to destroy tumors in their early stages [4-6]. For example, a mixture of L-ascorbic acid and cupric sulfate significantly inhibited human mammary tumor growth in mice, while administered orally [7]. L-Ascorbic acid and its derivatives were also shown to be cytotoxic and inhibited growth of a number of malignant and non-malignant cell lines in vitro and in vivo [8-11]. It has also been reported for L-ascorbic acid has to be cytotoxic to some human tumor cells, neuroblastoma [12], osteosarcoma and retinoblastoma [13]. A number of ascorbic acid isomers/derivatives were synthesized and tested on tumor cell lines so far. Substitution at 2- or 6- and both at 2, 6-positions in ascorbic acid have significant cytotoxicity potential on malignant cells [14]. Ascorbate-6-palmitate and ascorbate-6-stearate were found to be more potent inhibitors of growth of murine leukemia cells compared to ascorbate 2-phosphate, ascorbate-6-phosphate and ascorbate-6-sulphate respectively [14]. In addition, ascorbyl palmitate and ascorbyl stearate have attracted considerable interest as anticancer compounds in view of their lipophilic nature alowing them to easily cross cell membranes and blood brain barrier [15]. L-Ascorbic acid and ascorbyl esters have been shown to inhibit the proliferation of mouse glioma and human brain tumor cells, glioma (U-373) and glioblastoma (T98G) cells and renal carcinoma cells [16-18].

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mladen Mintas, )

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb